Summary
| Direction in GERD (Gastroesophageal Reflux Disease) | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Other |
| Compared against | healthy asymptomatic volunteers, patients with reflux hypersensitivity, and patients with functional heartburn |
| Source | Hoshikawa et al. 2020 — doi:10.5056/jnm19183 |
| Condition atlas | GERD (Gastroesophageal Reflux Disease) Biomarker Atlas |
Related Other markers in GERD (Gastroesophageal Reflux Disease)
Full list: GERD (Gastroesophageal Reflux Disease) Biomarker Atlas.
Frequently asked questions
Is Mean Nocturnal Baseline Impedance high or low in GERD (Gastroesophageal Reflux Disease)?
Reduced. Studies summarised in the OSMF atlas report lower Mean Nocturnal Baseline Impedance in GERD (Gastroesophageal Reflux Disease) than in healthy asymptomatic volunteers, patients with reflux hypersensitivity, and patients with functional heartburn. Source: Hoshikawa et al. 2020.
Which test measures Mean Nocturnal Baseline Impedance?
The atlas record does not list a standardised clinical test code (LOINC) for Mean Nocturnal Baseline Impedance, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal Mean Nocturnal Baseline Impedance result diagnostic of GERD (Gastroesophageal Reflux Disease)?
No. No single biomarker is diagnostic of GERD (Gastroesophageal Reflux Disease). Mean Nocturnal Baseline Impedance findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-10-08 · Page generated from gerd-gastroesophageal-reflux-disease.json · Browse: GERD (Gastroesophageal Reflux Disease) atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.