Research Tracker›Biomarker Atlas›GERD (Gastroesophageal Reflux Disease)›Pepsinogen I

Pepsinogen I in GERD (Gastroesophageal Reflux Disease)

In GERD (Gastroesophageal Reflux Disease), published studies report lower levels of Pepsinogen I than in healthy controls (without serologic AG). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Han et al. 2022 and reflects averages across cohorts rather than any single patient's result.

↓ ReducedGastrointestinal

Summary

Direction in GERD (Gastroesophageal Reflux Disease)↓ Reduced — lower than in the comparison group
CategoryGastrointestinal
Compared againsthealthy controls (without serologic AG)
SourceHan et al. 2022 — doi:10.3748/wjg.v28.i8.853
Condition atlasGERD (Gastroesophageal Reflux Disease) Biomarker Atlas

Related Gastrointestinal markers in GERD (Gastroesophageal Reflux Disease)

Full list: GERD (Gastroesophageal Reflux Disease) Biomarker Atlas.

Frequently asked questions

Is Pepsinogen I high or low in GERD (Gastroesophageal Reflux Disease)?

Reduced. Studies summarised in the OSMF atlas report lower Pepsinogen I in GERD (Gastroesophageal Reflux Disease) than in healthy controls (without serologic AG). Source: Han et al. 2022.

Which test measures Pepsinogen I?

The atlas record does not list a standardised clinical test code (LOINC) for Pepsinogen I, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal Pepsinogen I result diagnostic of GERD (Gastroesophageal Reflux Disease)?

No. No single biomarker is diagnostic of GERD (Gastroesophageal Reflux Disease). Pepsinogen I findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Pepsinogen I in GERD (Gastroesophageal Reflux Disease): direction, evidence and what it means. OSMF Research Tracker. Retrieved October 8, 2026, from https://research.opensourcemed.info/biomarkers/gerd-gastroesophageal-reflux-disease/pepsinogen-i.html
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Last reviewed: 2026-10-08 · Page generated from gerd-gastroesophageal-reflux-disease.json · Browse: GERD (Gastroesophageal Reflux Disease) atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.