COVID-19 vaccine (mRNA / spike-based)

Vaccine · intramuscular injection · 4 cohorts · 12 observations · CC BY 4.0

All PAIS cohorts in this database triggered by COVID-19 vaccine (mRNA / spike-based). Flags mark evidentiary caveats (preprint, grey literature, patient-reported, uncontrolled, etc.).

PACVS registry cohort (Semmler/Mundorf)

Cross-sectional · N=191 · control Healthy convenience · 5 obs · max follow-up 6 mo

Measures: Fatigue, Free tri-iodothyronine (low), Interleukin-6 (elevated), Interleukin-8 (elevated), Serum neurofilament light chain (elevated)

Comparative registry cohort of 191 people reporting post-acute COVID-19 vaccination syndrome (PACVS) vs 89 healthy controls, with serum biomarkers measured before and 6 months after vaccination. Distinguishes the vaccine trigger class (with Nohynek). Self-referred, not denominator-defined, so prevalence figures describe the affected registry, not a population; control-group values for individual markers were not extracted here and are marked measured_not_reported.

Post-Vac-Syndrom Deutschland patient survey grey literature not peer-reviewed patient-reported self-selected no control unverified source

Survey · N=777 · control None · 1 obs · max follow-up 6 mo

Measures: Paraesthesia / numbness

Flags: grey literature not peer-reviewed patient-reported self-selected no control unverified source

Grey-literature patient-organisation survey (n=777, Feb-Jun 2022) of people reporting post-vaccination symptoms in Germany. Not peer-reviewed and with no DOI/PMID, so it is admitted only as a flagged grey-literature source (allowed by a URL-only publication record) to represent the patient-advocacy end of the spectrum honestly. Most figures are subgroup percentages (e.g. among affected women); onset was within one week in 57% and within two weeks in a further 21%. Prevalence figures cannot be interpreted as population estimates.

VITAE vaccine-injury survey (Halma & Varon) preprint not peer-reviewed patient-reported self-selected no control author conflict

Survey · N=706 · control None · 2 obs · max follow-up 24 mo

Measures: Any persistent symptom, Not working due to illness

Flags: preprint not peer-reviewed patient-reported self-selected no control author conflict

Self-selected online survey (n=706) of people self-identifying as COVID-19 vaccine-injured, focused on disease burden and barriers to care rather than clinical symptom prevalence: chronic symptoms >=6 months in 91%, symptoms >2 years in ~80%, and large economic impact (about 70% of those employed dropped an income category; 26% became unemployed due to their condition). Flagged as a non-peer-reviewed preprint, patient-reported, self-selected, uncontrolled, with an author conflict. Included to represent the patient-advocacy end of the vaccine-trigger spectrum, explicitly labelled as such.

Yale LISTEN post-vaccination syndrome cohort (Krumholz)

Survey · N=241 · control None · 4 obs · max follow-up 20 mo

Measures: Cognitive dysfunction, Exercise intolerance, Fatigue, Paraesthesia / numbness

Self-selected online registry (Yale LISTEN) of 241 adults reporting post-vaccination syndrome after COVID-19 immunisation, surveyed a median of ~595 days (about 20 months) post-vaccination; no control group. A weak-design but broad symptom characterisation, with a linked immunological/antigen-signature analysis (Bhattacharjee 2025). Included to represent the self-report end of the vaccine-trigger spectrum; not denominator-defined for prevalence.