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PACVS registry cohort (Semmler/Mundorf)
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Design notes & limitations. Comparative registry cohort of 191 people reporting post-acute COVID-19 vaccination syndrome (PACVS) vs 89 healthy controls, with serum biomarkers measured before and 6 months after vaccination. Distinguishes the vaccine trigger class (with Nohynek). Self-referred, not denominator-defined, so prevalence figures describe the affected registry, not a population; control-group values for individual markers were not extracted here and are marked measured_not_reported.
Identity & trigger
- Cohort id
marburg-pacvs- Aliases
- Post-Acute COVID-19 Vaccination Syndrome registry, Marburg/Düsseldorf PACVS cohort
- Outbreak / event
- COVID-19 vaccination campaign (2021-)
- Pathogen
- COVID-19 vaccine (mRNA / spike-based) (Vaccine)
- Exposure ascertainment
- clinical diagnosis
Design
- Design
- Cross-sectional
- Denominator defined
- No
- Denominator method
- n/r
- Recruitment
- self referral
- Time zero
- First SARS-CoV-2 (mRNA) vaccination; chronic symptoms persisting >=5 months (month)
- Control group
- Healthy convenience
Size & attrition
- Enrolled
- 191
- Analysed / enrolled
- 191/191 (100%)
- Max follow-up (months)
- 6
Biospecimens
- Specimens
- Yes
- Types
- serum
- Acute-phase specimens
- No
- Biobank
- Unknown
- External access
- Unknown
Observations (5)
Symptoms
80% Proportion
- Measure
- Fatigue sym:fatigue
- As worded
- “malaise and chronic fatigue present in >80% of cases”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=191
- Timing
- 6 mo (3-6 mo) · ref Current
- Method
- Structured checklist
- Comparator
- Healthy convenience: measured, not reported
- Comparability signature
- c030cf0354 — measure sym:fatigue · Structured checklist · ref Current · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Abstract (>80% malaise and chronic fatigue) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Laboratory
60% Proportion
- Measure
- Interleukin-6 (elevated) lab:il-6
- As worded
- “elevated interleukin-6”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=191
- Timing
- 6 mo (3-6 mo) · ref Current
- Method
- Lab assay · threshold above reference range
- Comparator
- Healthy convenience: measured, not reported
- Comparability signature
- 1900d83c0d — measure lab:il-6 · Lab assay · ref Current · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results (elevated IL-6 in 60%) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
83% Proportion
- Measure
- Interleukin-8 (elevated) lab:il-8
- As worded
- “elevated interleukin-8 (reported 83-90%)”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=191
- Timing
- 6 mo (3-6 mo) · ref Current
- Method
- Lab assay · threshold above reference range
- Comparator
- Healthy convenience: measured, not reported
- Comparability signature
- 20b5845b4e — measure lab:il-8 · Lab assay · ref Current · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results (elevated IL-8, 83-90%) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
80% Proportion
- Measure
- Free tri-iodothyronine (low) lab:ft3-low
- As worded
- “reduced free tri-iodine thyroxine (>80%)”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=191
- Timing
- 6 mo (3-6 mo) · ref Current
- Method
- Lab assay · threshold below reference range
- Comparator
- Healthy convenience: measured, not reported
- Comparability signature
- 4f0dbfa6c7 — measure lab:ft3-low · Lab assay · ref Current · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results (low fT3 in >80%) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
27% Proportion
- Measure
- Serum neurofilament light chain (elevated) lab:snfl
- As worded
- “elevated soluble neurofilament light chains above the 90th percentile”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=191
- Timing
- 6 mo (3-6 mo) · ref Current
- Method
- Lab assay · threshold >90th percentile
- Comparator
- Healthy convenience: measured, not reported
- Comparability signature
- e71a8bb86a — measure lab:snfl · Lab assay · ref Current · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results (sNfL >90th percentile in 27%) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Mundorf AK, Semmler A, Heidecke H, et al. (2024). Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS). Vaccines (Basel). PMID 39066428 · DOI 10.3390/vaccines12070790 primary
- Semmler A, Mundorf AK, Kuechler AS, et al. (2023). Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers. Vaccines (Basel). PMID 38005974 · DOI 10.3390/vaccines11111642
Provenance & verification
- Registration
- n/r
- Funders
- not reported
- Related cohorts
- none
- Symptom-inventory scope
- Targeted panel
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)