Disease × agent pairs

Opioid Use Disorder: candidate agents with evidence

12 agents linked to Opioid Use Disorder by at least one registered trial or two publications, ranked by the OSMF evidence score. Not treatment advice.

Research Tracker › Pairs › Opioid Use Disorder

Buprenorphine

Drug · tier A · 8 trials (2 recruiting) · 17 publications · score 71.5

Nicotine

Drug · tier A · 8 trials (2 recruiting) · 13 publications · score 70.5

Methadone Hydrochloride

Drug · tier A · 8 trials (2 recruiting) · 7 publications · score 58.0

Buprenorphine Hydrochloride

Drug · tier A · 8 trials (2 recruiting) · 5 publications · score 51.5

Clonidine Hydrochloride

Drug · tier A · 7 trials (1 recruiting) · 5 publications · score 51.0

Lofexidine Hydrochloride

Drug · tier A · 8 trials (1 recruiting) · 2 publications · score 47.5

Levomethadyl Acetate

Drug · tier A · 1 trials (0 recruiting) · 5 publications · score 36.5

Norepinephrine

Drug · tier A · 1 trials (0 recruiting) · 5 publications · score 34.5

Yohimbine

Drug · tier A · 3 trials (0 recruiting) · 3 publications · score 33.0

Naloxone Hydrochloride Dihydrate

Drug · tier A · 2 trials (1 recruiting) · 1 publications · score 30.0

Methylnaltrexone Bromide

Drug · tier A · 2 trials (0 recruiting) · 0 publications · score 25.5

Ibogaine

Drug · tier C · 3 trials (1 recruiting) · 3 publications · score 21.0

Research map, not treatment advice. Built 2026-10-07.