Summary
Gabapentin Enacarbil has reached the approved stage (maximum clinical phase 4) for at least one indication, so its use in Irritable Bowel Syndrome (IBS) would be drug repurposing rather than first-in-human development. This does not mean it is approved for Irritable Bowel Syndrome (IBS). ClinicalTrials.gov lists 1 registered trial linking Gabapentin Enacarbil to Irritable Bowel Syndrome (IBS): 1 is terminated, withdrawn, suspended or of unknown status. The most advanced is Phase 4 (NCT01678911). It plans or enrolled 11 participants. Registered activity dates to 2012. No published literature item is linked to Gabapentin Enacarbil and Irritable Bowel Syndrome (IBS) in the OSMF database yet, so the record rests on registry entries alone. Registry entries describe intent to study, not outcomes.
The RepurpOS disease-intelligence file for Irritable Bowel Syndrome ranks 228 candidate therapeutics from Open Targets, ChEMBL, DGIdb and PubMed; only a minority carry direct clinical evidence, and this page covers one of those. Spontaneous remission context recorded for the condition: IBS is chronic and remitting; spontaneous 'remission' (symptom resolution without treatment) in ~30-40% at 2 years but symptom recurrence common; 10-20% develop persistent daily symptoms; <10% achieve permanent remission.
Evidence table
| Evidence tier | A · Strong |
|---|---|
| Evidence score | 22.5 (trials 2.5, literature 0.0, tier 15, approved bonus 5.0) |
| Registered trials | 1 total: 0 recruiting, 0 active / not yet recruiting, 0 completed, 1 other |
| Linked publications | 0 |
| Agent type | Drug (Small molecule) |
| Development stage (any indication) | Approved |
| Mechanism / class | modulator |
| Data sources | DGIdb |
| Linked via biomarker / target | CACNA1G |
How the evidence score is calculated
- Each registered trial scores by status (recruiting / active / enrolling 3, completed 2.5, not yet recruiting 2, unknown 1, terminated / withdrawn / suspended 0.5) plus a phase bonus (phase 3-4 +2, phase 2 +1, phase 1 +0.5). The trial component is capped at 30.
- Each literature item scores by design (Cochrane review 5, meta-analysis 4, systematic review 3, RCT 3, clinical trial publication 2, curated reference 1.5, other PubMed record 1). The literature component is capped at 30.
- The existing evidence tier adds 15 (A / Strong), 10 (B / Moderate), 5 (C / Preliminary) or 0 (D / Anecdotal).
- Agents approved for any indication (max clinical phase 4) add 5, because an approved agent has an established safety profile that lowers the barrier to repurposing trials.
- The score ranks what has been studied, not what works. It does not read effect sizes or directions of effect.
Registered clinical trials
| NCT ID | Title | Status | Phase | Enrolment |
|---|---|---|---|---|
| NCT01678911 | Efficacy of Gralise® for Chronic Pelvic Pain 2012 | terminated | Phase 4 | 11 |
Published literature
No publication is linked to this pair yet.
Mechanism and notes
Recorded mechanism or class: modulator.
OSMF's existing evidence tier for this pair is A (Strong), derived from the strength of the disease association recorded in DGIdb, in this case via the biomarker or target CACNA1G. The tier describes how well the drug-disease link is documented, not how well the drug works.
Frequently asked questions
Is Gabapentin Enacarbil approved for Irritable Bowel Syndrome (IBS)?
Gabapentin Enacarbil has reached the approved stage (maximum clinical phase 4) for at least one indication, so its use in Irritable Bowel Syndrome (IBS) would be drug repurposing rather than first-in-human development. This does not mean it is approved for Irritable Bowel Syndrome (IBS). Approval status for the specific indication should always be confirmed with the relevant regulator and prescribing information.
Is Gabapentin Enacarbil in clinical trials for Irritable Bowel Syndrome (IBS)?
ClinicalTrials.gov lists 1 registered trial linking Gabapentin Enacarbil to Irritable Bowel Syndrome (IBS): 1 is terminated, withdrawn, suspended or of unknown status. The most advanced is Phase 4 (NCT01678911). It plans or enrolled 11 participants. Registered activity dates to 2012.
What does the evidence show for Gabapentin Enacarbil in Irritable Bowel Syndrome (IBS)?
Trials of Gabapentin Enacarbil in Irritable Bowel Syndrome (IBS) are registered but none has completed, so there is no outcome evidence from those studies yet; the record is a signal of research interest. OSMF's existing evidence tier for this pair is A (Strong), derived from the strength of the disease association recorded in DGIdb, in this case via the biomarker or target CACNA1G. The tier describes how well the drug-disease link is documented, not how well the drug works.
Cite this page
Data: ClinicalTrials.gov, PubMed, Open Targets, ChEMBL, DGIdb and the OSMF therapeutic agent database. Last updated 2026-07-05. Page built 2026-10-07.