Summary
Ashwagandha has reached Preclinical as its most advanced recorded development stage across any indication, and the database holds no approval for Hypothyroidism. No registered clinical trial in this database tests Ashwagandha specifically in Hypothyroidism. The evidence below comes from published literature only, so any clinical signal has not yet been tested prospectively against this condition in a registered study. The literature layer holds 2 publications for this pair: 1 Cochrane review and 1 clinical trial publication. Publication years run from 2018 to 2023. Because at least one synthesis-level source exists (systematic review, meta-analysis or Cochrane review), this pair has been assessed beyond single studies, although the synthesis may concern a different indication.
The RepurpOS disease-intelligence file for Hypothyroidism ranks 81 candidate therapeutics from Open Targets, ChEMBL, DGIdb and PubMed; only a minority carry direct clinical evidence, and this page covers one of those. Spontaneous remission context recorded for the condition: Hashimoto's (most common cause) is irreversible in majority; spontaneous recovery in <5%; subclinical hypothyroidism spontaneously normalizes in ~30-40% of cases within 2 years without treatment.
Evidence table
| Evidence tier | C · Preliminary |
|---|---|
| Evidence score | 12.0 (trials 0.0, literature 7.0, tier 5, approved bonus 0.0) |
| Registered trials | 0 total: 0 recruiting, 0 active / not yet recruiting, 0 completed, 0 other |
| Linked publications | 2 (1 Cochrane review, 1 clinical trial publication) |
| Agent type | Supplement (Herbal) |
| Development stage (any indication) | Preclinical |
| Mechanism / class | Herbal treatments for hypothyroidism: an evidence-based review · Santiago JB, Martinez F, Durzynski N, Varon J, Halma M · 2025 |
| Data sources | OSMF Chronic Disease Review |
How the evidence score is calculated
- Each registered trial scores by status (recruiting / active / enrolling 3, completed 2.5, not yet recruiting 2, unknown 1, terminated / withdrawn / suspended 0.5) plus a phase bonus (phase 3-4 +2, phase 2 +1, phase 1 +0.5). The trial component is capped at 30.
- Each literature item scores by design (Cochrane review 5, meta-analysis 4, systematic review 3, RCT 3, clinical trial publication 2, curated reference 1.5, other PubMed record 1). The literature component is capped at 30.
- The existing evidence tier adds 15 (A / Strong), 10 (B / Moderate), 5 (C / Preliminary) or 0 (D / Anecdotal).
- Agents approved for any indication (max clinical phase 4) add 5, because an approved agent has an established safety profile that lowers the barrier to repurposing trials.
- The score ranks what has been studied, not what works. It does not read effect sizes or directions of effect.
Registered clinical trials
No registered trial links Ashwagandha to Hypothyroidism in the current OSMF trial extract.
Published literature
- Cochrane review Achievements in Hypothyroidism Treatment with Herbal Medicine: A Systematic Review of Randomized Controlled TrialsJavidi N, Khorasani ZM, Salari R et al. · Current drug discovery technologies · 2023 · PMID 37013429
- Clinical trial publication Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled TrialSharma AK, Basu I, Singh S · Journal of alternative and complementary medicine (New York, N.Y.) · 2018 · PMID 28829155
Mechanism and notes
Recorded mechanism or class: Herbal treatments for hypothyroidism: an evidence-based review · Santiago JB, Martinez F, Durzynski N, Varon J, Halma M · 2025.
OSMF's existing evidence tier for this pair is C (Preliminary), derived from the strength of the disease association recorded in OSMF Chronic Disease Review. The tier describes how well the drug-disease link is documented, not how well the drug works.
Frequently asked questions
Is Ashwagandha approved for Hypothyroidism?
Ashwagandha has reached Preclinical as its most advanced recorded development stage across any indication, and the database holds no approval for Hypothyroidism. Approval status for the specific indication should always be confirmed with the relevant regulator and prescribing information.
Is Ashwagandha in clinical trials for Hypothyroidism?
No registered clinical trial in this database tests Ashwagandha specifically in Hypothyroidism. The evidence below comes from published literature only, so any clinical signal has not yet been tested prospectively against this condition in a registered study.
What does the evidence show for Ashwagandha in Hypothyroidism?
Synthesis-level literature links Ashwagandha to Hypothyroidism, but no registered trial in this database tests the pair, so the evidence is observational, pooled from other indications, or pre-dates registry practice. OSMF's existing evidence tier for this pair is C (Preliminary), derived from the strength of the disease association recorded in OSMF Chronic Disease Review. The tier describes how well the drug-disease link is documented, not how well the drug works.
Cite this page
Data: ClinicalTrials.gov, PubMed, Open Targets, ChEMBL, DGIdb and the OSMF therapeutic agent database. Last updated 2026-07-05. Page built 2026-10-07.