Peer-Reviewed Literature Synthesis

Osteoarthritis Biomarker Atlas

Molecular alterations reported in Osteoarthritis compared to healthy controls, from peer-reviewed literature.

Spontaneous remissionStructural progression is essentially universal over 10+ years without intervention; pain fluctuates but functional…
Best-intervention remissionNo cure or disease modification available; total joint replacement (TJR) achieves 85-90% patient satisfaction and…
Gap sizeLarge for pain management vs disease modification (disease modification doesn't exist); moderate for functional…
Primary barrierbiological + practice
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Osteoarthritis patients relative to a named comparison population — not inferred.

5
Curated markers
2
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Bi et al. 2018

DOI: 10.1186/s13018-018-0959-y →
Peer-Reviewed Literature

Sipe et al. 1995

DOI: 10.1016/s0049-0172(95)80020-4 →
Peer-Reviewed Literature

Moskowitz et al. 2000

DOI: 10.1007/s11926-000-0022-x →
Peer-Reviewed Literature

Pu et al. 2021

DOI: 10.1055/a-1019-8117 →
Peer-Reviewed Literature

Cheng et al. 2020

DOI: 10.1177/1947603518798884 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

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