Peer-Reviewed Literature Synthesis

Osteoarthritis Biomarker Atlas

Molecular alterations reported in Osteoarthritis compared to healthy controls, from peer-reviewed literature.

Spontaneous remissionStructural progression is essentially universal over 10+ years without intervention; pain fluctuates but functional…
Best-intervention remissionNo cure or disease modification available; total joint replacement (TJR) achieves 85-90% patient satisfaction and…
Gap sizeLarge for pain management vs disease modification (disease modification doesn't exist); moderate for functional…
Primary barrierbiological + practice
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Osteoarthritis patients relative to a named comparison population — not inferred.

5
Curated markers
2
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Bi et al. 2018

DOI: 10.1186/s13018-018-0959-y →
Peer-Reviewed Literature

Sipe et al. 1995

DOI: 10.1016/s0049-0172(95)80020-4 →
Peer-Reviewed Literature

Moskowitz et al. 2000

DOI: 10.1007/s11926-000-0022-x →
Peer-Reviewed Literature

Pu et al. 2021

DOI: 10.1055/a-1019-8117 →
Peer-Reviewed Literature

Cheng et al. 2020

DOI: 10.1177/1947603518798884 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Individual Osteoarthritis biomarker pages

Each Osteoarthritis marker has its own page with direction, comparison group, symptoms, test details, citation and FAQ. Browse all marker pages.

Inflammatory

Musculoskeletal

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Osteoarthritis Biomarkers: 5 Blood Tests & Lab Markers. Research Tracker. https://research.opensourcemed.info/osteoarthritis-biomarkers.html (accessed )

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