Research Tracker›Biomarker Atlas›Osteoarthritis›Cartilage Oligomeric Matrix Protein (COMP)

Cartilage Oligomeric Matrix Protein (COMP) in Osteoarthritis

Cartilage Oligomeric Matrix Protein (COMP) is a musculoskeletal marker reported as elevated in Osteoarthritis when patients are compared with the reference group of the cited comparison (knee OA vs healthy controls). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The finding is drawn from Bi et al. 2018; it describes group-level differences, not a threshold that classifies an individual.

↑ ElevatedMusculoskeletal

Summary

Direction in Osteoarthritis↑ Elevated — higher than in the comparison group
CategoryMusculoskeletal
Compared againstknee OA vs healthy controls
SourceBi et al. 2018 — doi:10.1186/s13018-018-0959-y
Condition atlasOsteoarthritis Biomarker Atlas

Related Musculoskeletal markers in Osteoarthritis

Full list: Osteoarthritis Biomarker Atlas.

Frequently asked questions

Is Cartilage Oligomeric Matrix Protein (COMP) high or low in Osteoarthritis?

Elevated. Studies summarised in the OSMF atlas report higher Cartilage Oligomeric Matrix Protein (COMP) in Osteoarthritis than in the reference group of the cited comparison (knee OA vs healthy controls). Source: Bi et al. 2018.

Which test measures Cartilage Oligomeric Matrix Protein (COMP)?

The atlas record does not list a standardised clinical test code (LOINC) for Cartilage Oligomeric Matrix Protein (COMP), which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal Cartilage Oligomeric Matrix Protein (COMP) result diagnostic of Osteoarthritis?

No. No single biomarker is diagnostic of Osteoarthritis. Cartilage Oligomeric Matrix Protein (COMP) findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Cartilage Oligomeric Matrix Protein (COMP) in Osteoarthritis: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/osteoarthritis/cartilage-oligomeric-matrix-protein-comp.html
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Last reviewed: 2026-07-03 · Page generated from osteoarthritis.json · Browse: Osteoarthritis atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.