{
  "slug": "osteoarthritis",
  "id": "osteoarthritis-biomarkers",
  "condition": {
    "name": "Osteoarthritis",
    "shortName": "Osteoarthritis",
    "alternateNames": []
  },
  "page": {
    "title": "Osteoarthritis Biomarker Atlas | Blood Tests & Molecular Alterations",
    "breadcrumbName": "Osteoarthritis Biomarkers",
    "description": "Searchable atlas of Osteoarthritis biomarkers, from peer-reviewed literature comparing patient levels vs. healthy controls.",
    "keywords": [
      "Osteoarthritis biomarkers",
      "Osteoarthritis blood tests",
      "biomarker atlas",
      "biomarker database"
    ],
    "canonical": "https://research.opensourcemed.info/osteoarthritis-biomarkers.html",
    "hero": "Molecular alterations reported in Osteoarthritis compared to healthy controls, from peer-reviewed literature.",
    "dateModified": "2026-07-03"
  },
  "categories": {
    "inflammatory": "Inflammatory",
    "musculoskeletal": "Musculoskeletal"
  },
  "filters": [
    "inflammatory",
    "musculoskeletal"
  ],
  "markers": [
    {
      "name": "Cartilage Oligomeric Matrix Protein (COMP)",
      "alternateName": "Cartilage Oligomeric Matrix Protein (COMP)",
      "direction": "up",
      "category": "musculoskeletal",
      "comparison": "knee OA vs healthy controls",
      "symptoms": "",
      "reference": {
        "citation": "Bi et al. 2018",
        "doi": "10.1186/s13018-018-0959-y"
      }
    },
    {
      "name": "CRP",
      "alternateName": "CRP",
      "direction": "up",
      "category": "inflammatory",
      "comparison": "OA vs healthy (elevated but less than RA)",
      "symptoms": "",
      "reference": {
        "citation": "Sipe et al. 1995",
        "doi": "10.1016/s0049-0172(95)80020-4"
      },
      "testType": "BloodTest",
      "loinc": "1988-5"
    },
    {
      "name": "Hyaluronic Acid",
      "alternateName": "Hyaluronic Acid",
      "direction": "down",
      "category": "musculoskeletal",
      "comparison": "OA synovial fluid vs normal",
      "symptoms": "",
      "reference": {
        "citation": "Moskowitz et al. 2000",
        "doi": "10.1007/s11926-000-0022-x"
      }
    },
    {
      "name": "MMP-3",
      "alternateName": "MMP-3",
      "direction": "up",
      "category": "musculoskeletal",
      "comparison": "OA vs control",
      "symptoms": "",
      "reference": {
        "citation": "Pu et al. 2021",
        "doi": "10.1055/a-1019-8117"
      }
    },
    {
      "name": "Urinary CTX-II",
      "alternateName": "Urinary CTX-II",
      "direction": "up",
      "category": "musculoskeletal",
      "comparison": "knee OA vs healthy controls",
      "symptoms": "",
      "reference": {
        "citation": "Cheng et al. 2020",
        "doi": "10.1177/1947603518798884"
      }
    }
  ]
}