Remission & chronicity

Spontaneous remission

Structural progression is essentially universal over 10+ years without intervention; pain fluctuates but functional decline is the expected trajectory; no disease-modifying therapy exists as of 2024

Best-intervention remission

No cure or disease modification available; total joint replacement (TJR) achieves 85-90% patient satisfaction and near-elimination of pain but is not disease reversal; weight loss of >10% reduces pain scores ~50% and slows structural progression; exercise therapy comparable to NSAIDs for pain relief

Gap size

Large for pain management vs disease modification (disease modification doesn't exist); moderate for functional outcomes (exercise and weight loss underutilized vs medication)

Primary barrier

biological + practice

OARSI formally petitioned the FDA in 2016 to recognize OA as a serious disease with no cure and no disease-modifying interventions — confirmed in FDA's criteria. Practice gap: NSAIDs have been first-line for >100 years despite long-term evidence of joint damage acceleration and GI/CV risk; exercise consistently outperforms medication in functional outcomes but is rarely 'prescribed'

Biomarker Targets & Therapeutic Agents

Gene targets queried against DGIdb, Open Targets, ChEMBL, PubMed, and Europe PMC. Agents ranked: ● Clinical > ● Mechanistic > ● Correlative.

ACAN 0 ADAMTS5 196 COL2A1 3 CTNNB1 172 IL1B 218 IL6 173 MMP13 198 NGF 9 PTGS2 299 TNF 277

ACAN

UniProt Ensembl DGIdb Open Targets

Pipeline results not yet available for this target. Run the pipeline to populate.

ADAMTS5

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
ALDUMASTAT	↓ inhibits	Mechanistic		DGIdb
AGG-523	? unclear	Mechanistic	560.0 nM (IC50)	DGIdb
RECOMBINANT TUMOR NECROSIS FACTOR FAMILY PROTEIN	? unclear	Mechanistic		DGIdb
CHEMBL208009	↓ inhibits	Mechanistic	97.0 nM (Ki)	ChEMBL
CHEMBL207305	↓ inhibits	Mechanistic	1900.0 nM (Ki)	ChEMBL
CHEMBL230403	↓ inhibits	Mechanistic	20100.0 nM (IC50)	ChEMBL
CHEMBL396206	↓ inhibits	Mechanistic	1800.0 nM (IC50)	ChEMBL
CHEMBL231000	↓ inhibits	Mechanistic	1600.0 nM (IC50)	ChEMBL
CHEMBL230895	↓ inhibits	Mechanistic	1300.0 nM (IC50)	ChEMBL
CHEMBL230789	↓ inhibits	Mechanistic	11100.0 nM (IC50)	ChEMBL
CHEMBL230894	↓ inhibits	Mechanistic	1300.0 nM (IC50)	ChEMBL
CHEMBL230788	↓ inhibits	Mechanistic	1100.0 nM (IC50)	ChEMBL
CHEMBL387994	↓ inhibits	Mechanistic	900.0 nM (IC50)	ChEMBL
CHEMBL230683	↓ inhibits	Mechanistic	5300.0 nM (IC50)	ChEMBL
CHEMBL397040	↓ inhibits	Mechanistic	6700.0 nM (IC50)	ChEMBL
CHEMBL397937	↓ inhibits	Mechanistic	6800.0 nM (IC50)	ChEMBL
CHEMBL230726	↓ inhibits	Mechanistic	9200.0 nM (IC50)	ChEMBL
CHEMBL230725	↓ inhibits	Mechanistic	10000.0 nM (IC50)	ChEMBL
CHEMBL396218	↓ inhibits	Mechanistic	5300.0 nM (IC50)	ChEMBL
CHEMBL230723	↓ inhibits	Mechanistic	2500.0 nM (IC50)	ChEMBL
CHEMBL396217	↓ inhibits	Mechanistic	3200.0 nM (IC50)	ChEMBL
CHEMBL230621	↓ inhibits	Mechanistic	1700.0 nM (IC50)	ChEMBL
CHEMBL230620	↓ inhibits	Mechanistic	14800.0 nM (IC50)	ChEMBL
CHEMBL395985	↓ inhibits	Mechanistic	16200.0 nM (IC50)	ChEMBL
CHEMBL230619	↓ inhibits	Mechanistic	4900.0 nM (IC50)	ChEMBL
CHEMBL230516	↓ inhibits	Mechanistic	11600.0 nM (IC50)	ChEMBL
CHEMBL395503	↓ inhibits	Mechanistic	3500.0 nM (IC50)	ChEMBL
CHEMBL230514	↓ inhibits	Mechanistic	1400.0 nM (IC50)	ChEMBL
CHEMBL230408	↓ inhibits	Mechanistic	1800.0 nM (IC50)	ChEMBL
CHEMBL232565	↓ inhibits	Mechanistic	4200.0 nM (IC50)	ChEMBL
CHEMBL391693	↓ inhibits	Mechanistic	9000.0 nM (IC50)	ChEMBL
CHEMBL442073	↓ inhibits	Mechanistic	2100.0 nM (IC50)	ChEMBL
CHEMBL231740	↓ inhibits	Mechanistic	1100.0 nM (IC50)	ChEMBL
CHEMBL232364	↓ inhibits	Mechanistic	2500.0 nM (IC50)	ChEMBL
CHEMBL393113	↓ inhibits	Mechanistic	2200.0 nM (IC50)	ChEMBL
CHEMBL392264	↓ inhibits	Mechanistic	23200.0 nM (IC50)	ChEMBL
CHEMBL233333	↓ inhibits	Mechanistic	9100.0 nM (IC50)	ChEMBL
CHEMBL391928	↓ inhibits	Mechanistic	7100.0 nM (IC50)	ChEMBL
CHEMBL233132	↓ inhibits	Mechanistic	4200.0 nM (IC50)	ChEMBL
CHEMBL393991	↓ inhibits	Mechanistic	4600.0 nM (IC50)	ChEMBL

Showing top 40 of 196 agents ranked by evidence tier.

COL2A1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	? unclear	Mechanistic	DGIdb
OCRIPLASMIN	? unclear	Mechanistic	DGIdb
ALBUTEROL SULFATE	? unclear	Mechanistic	DGIdb

CTNNB1

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
PP1	↓ inhibits	Mechanistic	DGIdb
PF-670462	↓ inhibits	Mechanistic	DGIdb
MPI-0479605	? unclear	Mechanistic	DGIdb
SKF-86002	↓ inhibits	Mechanistic	DGIdb
SB203580	↓ inhibits	Mechanistic	DGIdb
IMATINIB	? unclear	Mechanistic	DGIdb
MAPK13-IN-1	↓ inhibits	Mechanistic	DGIdb
BAY1217389	? unclear	Mechanistic	DGIdb
NIROGACESTAT	? unclear	Mechanistic	DGIdb
NMS-P715	? unclear	Mechanistic	DGIdb
ACUMAPIMOD	↓ inhibits	Mechanistic	DGIdb
EOSIN_Y	? unclear	Mechanistic	DGIdb
DILMAPIMOD	↓ inhibits	Mechanistic	DGIdb
PRI-724	↓ inhibits	Mechanistic	DGIdb
MW150	↓ inhibits	Mechanistic	DGIdb
COMPOUND 12 [PMID: 22521646]	↓ inhibits	Mechanistic	DGIdb
BMS-582949	↓ inhibits	Mechanistic	DGIdb
OSUGACESTAT	? unclear	Mechanistic	DGIdb
AZD7624	↓ inhibits	Mechanistic	DGIdb
VANTICTUMAB	? unclear	Mechanistic	DGIdb
ANTI-PD-L1 MONOCLONAL ANTIBODY	? unclear	Mechanistic	DGIdb
LOSMAPIMOD	↓ inhibits	Mechanistic	DGIdb
LENALIDOMIDE	? unclear	Mechanistic	DGIdb
NDPPC	↓ inhibits	Mechanistic	DGIdb
CELECOXIB	? unclear	Mechanistic	DGIdb
TRAMETINIB DIMETHYL SULFOXIDE	? unclear	Mechanistic	DGIdb
DORAMAPIMOD	↓ inhibits	Mechanistic	DGIdb
CHEMBL:CHEMBL2172378	? unclear	Mechanistic	DGIdb
RECOMBINANT HUMAN ENDOSTATIN	? unclear	Mechanistic	DGIdb
TRICIRIBINE	? unclear	Mechanistic	DGIdb
TEMSIROLIMUS	? unclear	Mechanistic	DGIdb
AZD6703	↓ inhibits	Mechanistic	DGIdb
SAM68 MODULATOR CWP232291	? unclear	Mechanistic	DGIdb
NEFLAMAPIMOD	↓ inhibits	Mechanistic	DGIdb
LETROZOLE	? unclear	Mechanistic	DGIdb
VX-702	↓ inhibits	Mechanistic	DGIdb
7-HYDROXYSTAUROSPORINE	↓ inhibits	Mechanistic	DGIdb
TAK-715	↓ inhibits	Mechanistic	DGIdb
FLUORESCEIN SODIUM	? unclear	Mechanistic	DGIdb
PEXMETINIB	↓ inhibits	Mechanistic	DGIdb

Showing top 40 of 172 agents ranked by evidence tier.

IL1B

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
ASPIRIN	? unclear	Mechanistic	DGIdb
MAFOSFAMIDE	? unclear	Mechanistic	DGIdb
DIACETYLRHEIN	? unclear	Mechanistic	DGIdb
INFLIXIMAB	? unclear	Mechanistic	DGIdb
LANSOPRAZOLE	? unclear	Mechanistic	DGIdb
TILUDRONIC ACID	? unclear	Mechanistic	DGIdb
GEVOKIZUMAB	~ modulates	Mechanistic	DGIdb
LUTIKIZUMAB	↓ inhibits	Mechanistic	DGIdb
CELASTROL	? unclear	Mechanistic	DGIdb
CYTARABINE	? unclear	Mechanistic	DGIdb
RILONACEPT	↓ inhibits	Mechanistic	DGIdb
TT-301	? unclear	Mechanistic	DGIdb
METFORMIN	? unclear	Mechanistic	DGIdb
ANTICONVULSANT AGENT	? unclear	Mechanistic	DGIdb
ANTIDEPRESSANT AGENT	? unclear	Mechanistic	DGIdb
ACITRETIN	? unclear	Mechanistic	DGIdb
ERYTHROMYCIN	? unclear	Mechanistic	DGIdb
ALTEPLASE	? unclear	Mechanistic	DGIdb
OFLOXACIN	? unclear	Mechanistic	DGIdb
PENTOXIFYLLINE	? unclear	Mechanistic	DGIdb
USTEKINUMAB	? unclear	Mechanistic	DGIdb
LITHIUM	? unclear	Mechanistic	DGIdb
RALOXIFENE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
MITOGEN-ACTIVATED PROTEIN KINASE INHIBITOR	? unclear	Mechanistic	DGIdb
DRUGSATFDA.NDA:008378	? unclear	Mechanistic	DGIdb
NICARDIPINE	? unclear	Mechanistic	DGIdb
GLUCOSAMINE	? unclear	Mechanistic	DGIdb
BECLOMETHASONE DIPROPIONATE	? unclear	Mechanistic	DGIdb
PAREGORIC	? unclear	Mechanistic	DGIdb
CEFACLOR ANHYDROUS	? unclear	Mechanistic	DGIdb
IBUDILAST	? unclear	Mechanistic	DGIdb
MELATONIN	? unclear	Mechanistic	DGIdb
PENTAMIDINE	? unclear	Mechanistic	DGIdb
PRAVASTATIN SODIUM	? unclear	Mechanistic	DGIdb
VERAPAMIL	? unclear	Mechanistic	DGIdb
THYROGLOBULIN	? unclear	Mechanistic	DGIdb
RISEDRONIC ACID	? unclear	Mechanistic	DGIdb
AUTOANTIGEN	? unclear	Mechanistic	DGIdb
CDP-484	↓ inhibits	Mechanistic	DGIdb
ETIDRONIC ACID	? unclear	Mechanistic	DGIdb

Showing top 40 of 218 agents ranked by evidence tier.

IL6

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Source
CISPLATIN	? unclear	Mechanistic	DGIdb
ZILTIVEKIMAB	~ modulates	Mechanistic	DGIdb
CHINESE HERBS	? unclear	Mechanistic	DGIdb
PF-04236921	↓ inhibits	Mechanistic	DGIdb
MRA 003 US	↓ inhibits	Mechanistic	DGIdb
SIGNAL TRANSDUCTION INHIBITOR	? unclear	Mechanistic	DGIdb
BINETRAKIN	? unclear	Mechanistic	DGIdb
IBUDILAST	? unclear	Mechanistic	DGIdb
INSULIN, REGULAR, HUMAN	? unclear	Mechanistic	DGIdb
SILTUXIMAB	↓ inhibits	Mechanistic	DGIdb
METRONIDAZOLE	? unclear	Mechanistic	DGIdb
CLAZAKIZUMAB	↓ inhibits	Mechanistic	DGIdb
GALLIUM NITRATE	? unclear	Mechanistic	DGIdb
INTERFERON ALFA-2B	? unclear	Mechanistic	DGIdb
DULOXETINE HYDROCHLORIDE	? unclear	Mechanistic	DGIdb
MEDI-5117	↓ inhibits	Mechanistic	DGIdb
GEMFIBROZIL	? unclear	Mechanistic	DGIdb
BIAFINE CREAM	? unclear	Mechanistic	DGIdb
ETANERCEPT	? unclear	Mechanistic	DGIdb
ELSILIMOMAB	↓ inhibits	Mechanistic	DGIdb
SAQUINAVIR	? unclear	Mechanistic	DGIdb
INFLIXIMAB	? unclear	Mechanistic	DGIdb
LINEZOLID	? unclear	Mechanistic	DGIdb
IFOSFAMIDE	? unclear	Mechanistic	DGIdb
OLOKIZUMAB	↓ inhibits	Mechanistic	DGIdb
HMG-COA REDUCTASE INHIBITOR	? unclear	Mechanistic	DGIdb
MIDOSTAURIN	? unclear	Mechanistic	DGIdb
SELENIUM	? unclear	Mechanistic	DGIdb
SIRUKUMAB	↓ inhibits	Mechanistic	DGIdb
PEGINTERFERON ALFA-2B	? unclear	Mechanistic	DGIdb
ECHINACEA PREPARATION	? unclear	Mechanistic	DGIdb
ENZYME INHIBITOR	? unclear	Mechanistic	DGIdb
FENOFIBRATE MICRONIZED	? unclear	Mechanistic	DGIdb
VITAMIN K	? unclear	Mechanistic	DGIdb
PEGINTERFERON ALFA-2A	? unclear	Mechanistic	DGIdb
RIBAVIRIN	? unclear	Mechanistic	DGIdb
VITAMIN A PALMITATE	? unclear	Mechanistic	DGIdb
ARSENIC TRIOXIDE	? unclear	Mechanistic	DGIdb
DIHYDROSPHINGOSINE	? unclear	Mechanistic	DGIdb
LEVOFLOXACIN ANHYDROUS	? unclear	Mechanistic	DGIdb

Showing top 40 of 173 agents ranked by evidence tier.

MMP13

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
CURCUMIN	? unclear	Mechanistic		DGIdb
REBIMASTAT	↓ inhibits	Mechanistic		DGIdb
DOXYCYCLINE CALCIUM	↓ inhibits	Mechanistic		DGIdb
APRATASTAT	↓ inhibits	Mechanistic		DGIdb
PRINOMASTAT	? unclear	Mechanistic	1.5 nM (IC50)	DGIdb
DOXYCYCLINE ANHYDROUS	↓ inhibits	Mechanistic		DGIdb
CTS-1027	↓ inhibits	Mechanistic	2.0 nM (IC50)	DGIdb
ILOMASTAT	? unclear	Mechanistic		DGIdb
DOXYCYCLINE HYCLATE	? unclear	Mechanistic		Open Targets
DOXYCYCLINE	? unclear	Mechanistic		Open Targets
CHEMBL348210	↓ inhibits	Mechanistic	3.0 nM (IC50)	ChEMBL
CHEMBL80814	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL346624	↓ inhibits	Mechanistic	0.7 nM (IC50)	ChEMBL
CHEMBL276119	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL78934	↓ inhibits	Mechanistic	5.0 nM (IC50)	ChEMBL
CHEMBL78369	↓ inhibits	Mechanistic	1.0 nM (IC50)	ChEMBL
CGS-27023A	↓ inhibits	Mechanistic	8.0 nM (IC50)	ChEMBL
CHEMBL151591	↓ inhibits	Mechanistic	3.0 nM (IC50)	ChEMBL
CHEMBL80453	↓ inhibits	Mechanistic	4.0 nM (IC50)	ChEMBL
CHEMBL312432	↓ inhibits	Mechanistic	6.0 nM (IC50)	ChEMBL
CHEMBL150655	↓ inhibits	Mechanistic	0.2 nM (IC50)	ChEMBL
CHEMBL306617	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL79111	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL78798	↓ inhibits	Mechanistic	1.0 nM (IC50)	ChEMBL
CHEMBL440355	↓ inhibits	Mechanistic	0.5 nM (IC50)	ChEMBL
CHEMBL80969	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL78909	↓ inhibits	Mechanistic	1.0 nM (IC50)	ChEMBL
CHEMBL76137	↓ inhibits	Mechanistic	3.0 nM (IC50)	ChEMBL
CHEMBL310340	↓ inhibits	Mechanistic	1.4 nM (IC50)	ChEMBL
CHEMBL150027	↓ inhibits	Mechanistic	0.4 nM (IC50)	ChEMBL
CHEMBL346442	↓ inhibits	Mechanistic	0.2 nM (IC50)	ChEMBL
CHEMBL76836	↓ inhibits	Mechanistic	3.0 nM (IC50)	ChEMBL
CHEMBL150077	↓ inhibits	Mechanistic	0.3 nM (IC50)	ChEMBL
CHEMBL357796	↓ inhibits	Mechanistic	8.0 nM (IC50)	ChEMBL
CHEMBL312429	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL78549	↓ inhibits	Mechanistic	1.0 nM (IC50)	ChEMBL
CHEMBL78508	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL80732	↓ inhibits	Mechanistic	2.0 nM (IC50)	ChEMBL
CHEMBL309311	↓ inhibits	Mechanistic	1.0 nM (IC50)	ChEMBL
CHEMBL151399	↓ inhibits	Mechanistic	4.0 nM (IC50)	ChEMBL

Showing top 40 of 198 agents ranked by evidence tier.

NGF

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
MEDI-578	↓ inhibits	Mechanistic		DGIdb
CERE-110	? unclear	Mechanistic		DGIdb
FASINUMAB	↓ inhibits	Mechanistic		DGIdb
TANEZUMAB	↓ inhibits	Mechanistic		DGIdb
FRUNEVETMAB	~ modulates	Mechanistic		DGIdb
FULRANUMAB	↓ inhibits	Mechanistic		DGIdb
BEDINVETMAB	~ modulates	Mechanistic		DGIdb
PG-110	↓ inhibits	Mechanistic		DGIdb
CHEMBL1397270	↓ inhibits	Mechanistic	1000.0 nM (IC50)	ChEMBL

PTGS2

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
CARPROFEN	↓ inhibits	Mechanistic	102.0 nM (IC50)	DGIdb
INDOMETHACIN SODIUM	↓ inhibits	Mechanistic		DGIdb
DARBUFELONE	? unclear	Mechanistic		DGIdb
MEFENAMIC ACID	↓ inhibits	Mechanistic		DGIdb
MECLOFENAMATE SODIUM	↓ inhibits	Mechanistic		DGIdb
DICLOFENAC SODIUM	↓ inhibits	Mechanistic		DGIdb
CAPECITABINE	? unclear	Mechanistic		DGIdb
PIRPROFEN	↓ inhibits	Mechanistic		DGIdb
ESFLURBIPROFEN	↓ inhibits	Mechanistic		DGIdb
SULFASALAZINE	↓ inhibits	Mechanistic		DGIdb
BROMFENAC	? unclear	Mechanistic		DGIdb
IBUPROFEN, SODIUM SALT	↓ inhibits	Mechanistic		DGIdb
ALOXIPRIN	↓ inhibits	Mechanistic		DGIdb
TENOXICAM	? unclear	Mechanistic		DGIdb
FLURBIPROFEN	↓ inhibits	Mechanistic		DGIdb
SALICYLIC ACID	? unclear	Mechanistic		DGIdb
ATENOLOL	? unclear	Mechanistic		DGIdb
DEXKETOPROFEN	↓ inhibits	Mechanistic		DGIdb
ETORICOXIB	↓ inhibits	Mechanistic		DGIdb
LUMIRACOXIB	↓ inhibits	Mechanistic		DGIdb
SUPROFEN	↓ inhibits	Mechanistic		DGIdb
NS-398	? unclear	Mechanistic		DGIdb
NABUMETONE	↓ inhibits	Mechanistic		DGIdb
URSOLIC ACID	? unclear	Mechanistic		DGIdb
IBUPROFEN LYSINE	↓ inhibits	Mechanistic		DGIdb
ACECLOFENAC	↓ inhibits	Mechanistic		DGIdb
IBUFENAC	↓ inhibits	Mechanistic		DGIdb
BALSALAZIDE	? unclear	Mechanistic		DGIdb
DIFLUNISAL	↓ inhibits	Mechanistic		DGIdb
BALSALAZIDE DISODIUM	↓ inhibits	Mechanistic		DGIdb
VACCINE	? unclear	Mechanistic		DGIdb
KETOROLAC TROMETHAMINE	↓ inhibits	Mechanistic		DGIdb
BENZYDAMINE HYDROCHLORIDE	↓ inhibits	Mechanistic		DGIdb
TIAPROFENIC ACID	? unclear	Mechanistic		DGIdb
RALOXIFENE HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
NAPROXCINOD	↓ inhibits	Mechanistic		DGIdb
IGURATIMOD	↓ inhibits	Mechanistic		DGIdb
ETODOLAC	↓ inhibits	Mechanistic		DGIdb
DICLOFENAC ETALHYALURONATE SODIUM	↓ inhibits	Mechanistic		DGIdb
ROFECOXIB	↓ inhibits	Mechanistic	530.0 nM (IC50)	DGIdb

Showing top 40 of 299 agents ranked by evidence tier.

TNF

UniProt Ensembl DGIdb Open Targets

Therapeutic Agent	Effect Direction	Evidence Tier	Potency	Source
NERELIMOMAB	↓ inhibits	Mechanistic		DGIdb
CROMOLYN SODIUM	? unclear	Mechanistic		DGIdb
PLACULUMAB	↓ inhibits	Mechanistic		DGIdb
METHYLENE BLUE	? unclear	Mechanistic		DGIdb
ALTEPLASE	? unclear	Mechanistic		DGIdb
CARBOPLATIN	? unclear	Mechanistic		DGIdb
GENTAMICIN	? unclear	Mechanistic		DGIdb
GOLIMUMAB	↓ inhibits	Mechanistic		DGIdb
BUPIVACAINE	? unclear	Mechanistic		DGIdb
PENTOXIFYLLINE	? unclear	Mechanistic	85000.0 nM (IC50)	DGIdb
BENZO[E]PYRENE	? unclear	Mechanistic		DGIdb
THALIDOMIDE	? unclear	Mechanistic		DGIdb
PYRAZINAMIDE	? unclear	Mechanistic		DGIdb
GLIMEPIRIDE	? unclear	Mechanistic		DGIdb
OMEPRAZOLE	? unclear	Mechanistic		DGIdb
LENERCEPT	↓ inhibits	Mechanistic		DGIdb
ADALIMUMAB	↓ inhibits	Mechanistic		DGIdb
PRAZOSIN HYDROCHLORIDE	? unclear	Mechanistic		DGIdb
REMTOLUMAB	? unclear	Mechanistic		DGIdb
MIDOSTAURIN	? unclear	Mechanistic		DGIdb
LENABASUM	? unclear	Mechanistic		DGIdb
MAGNESIUM SULFATE ANHYDROUS	? unclear	Mechanistic		DGIdb
PICIBANIL	? unclear	Mechanistic		DGIdb
FLUOCINOLONE ACETONIDE	? unclear	Mechanistic		DGIdb
MILTEFOSINE	? unclear	Mechanistic		DGIdb
HOMIDIUM BROMIDE	? unclear	Mechanistic		DGIdb
OZORALIZUMAB	↓ inhibits	Mechanistic		DGIdb
PEGSUNERCEPT	↓ inhibits	Mechanistic		DGIdb
CERTOLIZUMAB PEGOL	↓ inhibits	Mechanistic		DGIdb
THERAPEUTIC HORMONE	? unclear	Mechanistic		DGIdb
NAFAMOSTAT	? unclear	Mechanistic		DGIdb
FOLIC ACID	? unclear	Mechanistic		DGIdb
ABBV-257	? unclear	Mechanistic		DGIdb
RISPERIDONE	? unclear	Mechanistic		DGIdb
COVA322	? unclear	Mechanistic		DGIdb
HYDROXYCHLOROQUINE	? unclear	Mechanistic		DGIdb
CERTOLIZUMAB	? unclear	Mechanistic		DGIdb
AN0128	? unclear	Mechanistic		DGIdb
5,7-DIHYDROXY-4-METHYLCOUMARIN	? unclear	Mechanistic		DGIdb
SORAFENIB	? unclear	Mechanistic		DGIdb

Showing top 40 of 277 agents ranked by evidence tier.

Clinical Trials

Recruiting and recently completed trials from ClinicalTrials.gov. Data retrieved 2026-07-06.

No recent clinical trials found on ClinicalTrials.gov for this condition.

Agents Found By Disease-Level Search

Searched directly from “Osteoarthritis” via ClinicalTrials.gov interventions and Open Targets' disease→drug data — independent of the 10-gene target panel above. This surfaces agents whose mechanism doesn't route through a curated gene (combination therapies, standard-of-care drugs, targets outside the panel).

60 agents shown (approved or with trial evidence) — 59 not found by the gene-target search above.

transient immune-modulationNOT in gene-target list

· 2 trials · source: ClinicalTrials.gov
NCT05835895 NCT05835895

FX006 32 mgNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02762370

TCA IR 40 mgNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02762370

Kaia hip and knee pain applicationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04615377

DELTA Revision acetabular cupNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06359301

Ketoprofen Topical Patch , 20%NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00365586

MPact CupNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03897595

YYD302 2mlNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02965495

YYD302 3mlNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02965495

Placebo 3mlNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02965495

GNSC-001NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05835895

Fit & Strong!NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04536727

Wait listNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04536727

tai chiNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03660254

Corticosteroid injection (CSI)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07217405

Low-dose radiotherapy (LDRT)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07217405

stem cell injectionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01499056

Autologous cell therapyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03984461

Operative (partial arthroscopy)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00549172

Conservative (diagnostic arthroscopy)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00549172

chondroitin sulfateNOT in gene-target list

Phase 3 · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT02079727

celecoxib

Approved · 1 trial · source: ClinicalTrials.gov, Open Targets
NCT02079727

Non-image-based Computer-Assisted Navigation with Bone MorphingNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07574775

P.F.C. Sigma KneeNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00734019

Sodium Hyaluronate (Hyalgan)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01267214

Osteotomy aloneNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01267214

Medacta GMK Sphere® Medial Knee ProsthesisNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02501733

TriathlonNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT05842538

Total knee replacement with the ROCC® knee prosthesisNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02127619

AS Domelock SystemNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03312465

Vitamin DNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01176344

Total Hip ArthroplastyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06640764

OraVescent FentanylNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00343733

Lifestyles ANOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01142349

Lifestyles BNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01142349

Lifestyles CNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01142349

Aquamid reconstructionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03060421

Stem Cell Support FormulaNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04661267

Application ARTHeNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04750304

Zimmer Patient specific instrumentsNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02096393

Standard instrumentationNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02096393

Pregabalin or Duloxetine or PlaceboNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02612233

barbed sutureNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03031314

standard sutureNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03031314

Tapentadol (CG5503) Extended Release (ER)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT00487435

Synvisc-One (hylan G-F 20)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01618708

Vivacit-E LinerNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT03226808

Liposomal bupivacaineNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02762071

Interscalene Nerve BlockNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02762071

BioPolyNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06915363

surgical standard of care (SSOC)NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06915363

Flywheel exerciseNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04588558

Electrotherapy groupNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04588558

Evicel fibrin sealantNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01235715

Traumeel® / Zeel® Injectable SolutionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT01887678

injection of Filtered Autologous Adipose TissueNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04567732

SM04690NOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT02536833

ESWTNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT04243135

Nudge interventionNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT07330492

CATALYSTEMNOT in gene-target list

· 1 trial · source: ClinicalTrials.gov
NCT06564636

Osteoarthritis

Remission & chronicity

ACAN

ADAMTS5

COL2A1

CTNNB1

IL1B

IL6

MMP13

NGF

PTGS2

TNF

transient immune-modulationNOT in gene-target list

FX006 32 mgNOT in gene-target list

TCA IR 40 mgNOT in gene-target list

Kaia hip and knee pain applicationNOT in gene-target list

DELTA Revision acetabular cupNOT in gene-target list

Ketoprofen Topical Patch , 20%NOT in gene-target list

MPact CupNOT in gene-target list

YYD302 2mlNOT in gene-target list

YYD302 3mlNOT in gene-target list

Placebo 3mlNOT in gene-target list

GNSC-001NOT in gene-target list

Fit & Strong!NOT in gene-target list

Wait listNOT in gene-target list

tai chiNOT in gene-target list

Corticosteroid injection (CSI)NOT in gene-target list

Low-dose radiotherapy (LDRT)NOT in gene-target list

stem cell injectionNOT in gene-target list

Autologous cell therapyNOT in gene-target list

Operative (partial arthroscopy)NOT in gene-target list

Conservative (diagnostic arthroscopy)NOT in gene-target list

chondroitin sulfateNOT in gene-target list

celecoxib

Non-image-based Computer-Assisted Navigation with Bone MorphingNOT in gene-target list

P.F.C. Sigma KneeNOT in gene-target list

Sodium Hyaluronate (Hyalgan)NOT in gene-target list

Osteotomy aloneNOT in gene-target list

Medacta GMK Sphere® Medial Knee ProsthesisNOT in gene-target list

TriathlonNOT in gene-target list

Total knee replacement with the ROCC® knee prosthesisNOT in gene-target list

AS Domelock SystemNOT in gene-target list

Vitamin DNOT in gene-target list

Total Hip ArthroplastyNOT in gene-target list

OraVescent FentanylNOT in gene-target list

Lifestyles ANOT in gene-target list

Lifestyles BNOT in gene-target list

Lifestyles CNOT in gene-target list

Aquamid reconstructionNOT in gene-target list

Stem Cell Support FormulaNOT in gene-target list

Application ARTHeNOT in gene-target list

Zimmer Patient specific instrumentsNOT in gene-target list

Standard instrumentationNOT in gene-target list

Pregabalin or Duloxetine or PlaceboNOT in gene-target list

barbed sutureNOT in gene-target list

standard sutureNOT in gene-target list

Tapentadol (CG5503) Extended Release (ER)NOT in gene-target list

Synvisc-One (hylan G-F 20)NOT in gene-target list

Vivacit-E LinerNOT in gene-target list

Liposomal bupivacaineNOT in gene-target list

Interscalene Nerve BlockNOT in gene-target list

BioPolyNOT in gene-target list

surgical standard of care (SSOC)NOT in gene-target list

Flywheel exerciseNOT in gene-target list

Electrotherapy groupNOT in gene-target list

Evicel fibrin sealantNOT in gene-target list

Traumeel® / Zeel® Injectable SolutionNOT in gene-target list

injection of Filtered Autologous Adipose TissueNOT in gene-target list

SM04690NOT in gene-target list

ESWTNOT in gene-target list

Nudge interventionNOT in gene-target list

CATALYSTEMNOT in gene-target list

Part of the Open Source Medicine Foundation Network