Peer-Reviewed Literature Synthesis

Hepatitis C Biomarker Atlas

Molecular alterations reported in Hepatitis C compared to healthy controls, from peer-reviewed literature.

US DALYs146.1KWHO GHE 2021 · all ages
Global DALYs4.70MWHO GHE 2021 · worldwide
US mortality4,555 deaths/yrWHO GHE 2021
Global mortality88.1K deaths/yrWHO GHE 2021 · worldwide
NIH funding$86MFY2025 · RCDC estimate
Funding levelWell-Funded
Spontaneous remissionSpontaneous clearance in <30% of acute cases; chronic infection rarely clears without treatment (<1%/year)
Best-intervention remission>95% cured (sustained virologic response at 12 weeks) with 8-12 week courses of direct-acting antivirals (DAAs)
Gap sizeNear-zero biological gap; large access/utilization gap
Primary barrieraccess
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Hepatitis C patients relative to a named comparison population — not inferred.

9
Curated markers
3
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Nakao et al. 2013

DOI: 10.1111/hepr.12052 →
Peer-Reviewed Literature

Woo et al. 2024

DOI: 10.3390/pathogens13040331 →
Peer-Reviewed Literature

Al-Rawaf et al. 2024

DOI: 10.1186/s12860-024-00514-8 →
Peer-Reviewed Literature

Siagris et al. 2002

DOI: 10.1007/s15010-002-2085-2 →
Peer-Reviewed Literature

Krassenburg et al. 2023

DOI: 10.1136/bmjgast-2023-001209 →
Peer-Reviewed Literature

Khadem Ansari et al. 2015

DOI: 10.5812/hepatmon.22069 →
Peer-Reviewed Literature

Dibba et al. 2018

DOI: 10.3390/diseases6020031 →
Peer-Reviewed Literature

Voumvouraki et al. 2011

DOI: 10.1016/j.ejim.2010.10.002 →
Peer-Reviewed Literature

Fontana et al. 2002

DOI: 10.1053/jhep.2002.36800 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Individual Hepatitis C biomarker pages

Each Hepatitis C marker has its own page with direction, comparison group, symptoms, test details, citation and FAQ. Browse all marker pages.

Hepatic

Musculoskeletal

Other

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Hepatitis C Biomarkers: 9 Blood Tests & Lab Markers. Research Tracker. https://research.opensourcemed.info/hepatitis-c-biomarkers.html (accessed )

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