Research Tracker›Biomarker Atlas›Hepatitis C›FIB-4 Index

FIB-4 Index in Hepatitis C

In Hepatitis C, published studies report higher levels of FIB-4 Index, also described as FIB-4, than in the reference group of the cited comparison (chronic HCV patients with advanced liver fibrosis vs early-stage disease (FIB-4 <1.45)). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Krassenburg et al. 2023 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedHepatic

Summary

Direction in Hepatitis C↑ Elevated — higher than in the comparison group
CategoryHepatic
Also described asFIB-4
Compared againstchronic HCV patients with advanced liver fibrosis vs early-stage disease (FIB-4 <1.45)
SourceKrassenburg et al. 2023 — doi:10.1136/bmjgast-2023-001209
Condition atlasHepatitis C Biomarker Atlas

Related Hepatic markers in Hepatitis C

Full list: Hepatitis C Biomarker Atlas.

Frequently asked questions

Is FIB-4 Index high or low in Hepatitis C?

Elevated. Studies summarised in the OSMF atlas report higher FIB-4 Index in Hepatitis C than in the reference group of the cited comparison (chronic HCV patients with advanced liver fibrosis vs early-stage disease (FIB-4 <1.45)). Source: Krassenburg et al. 2023.

Which test measures FIB-4 Index?

The atlas record does not list a standardised clinical test code (LOINC) for FIB-4 Index, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal FIB-4 Index result diagnostic of Hepatitis C?

No. No single biomarker is diagnostic of Hepatitis C. FIB-4 Index findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). FIB-4 Index in Hepatitis C: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/hepatitis-c/fib-4-index.html
Get OSMF research updates. New biomarker, trial and treatment evidence summaries by email.
Subscribe on Substack

Last reviewed: 2026-07-03 · Page generated from hepatitis-c.json · Browse: Hepatitis C atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.