Peer-Reviewed Literature Synthesis

Chronic Kidney Disease Biomarker Atlas

Molecular alterations reported in Chronic Kidney Disease compared to healthy controls, from peer-reviewed literature.

Spontaneous remissionGFR decline averages 2-5 mL/min/year on standard care (ACE/ARB + blood pressure control); progression to end-stage…
Best-intervention remissionSGLT2 inhibitors (empagliflozin, dapagliflozin) reduce progression to ESRD by 30-35% in CKD trials (EMPA-KIDNEY…
Gap sizeModerate — SGLT2 inhibitors represent a genuine paradigm shift but are dramatically underused
Primary barrierpractice/access
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Chronic Kidney Disease patients relative to a named comparison population — not inferred.

6
Curated markers
1
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Taglieri et al. 2009

DOI: 10.1373/clinchem.2009.128397 →
Peer-Reviewed Literature

Li et al. 2024

DOI: 10.3389/fendo.2024.1329256 →
Peer-Reviewed Literature

Jamal et al. 2013

DOI: 10.1016/j.jocd.2012.11.012 →
Peer-Reviewed Literature

Benoit et al. 2020

DOI: 10.1080/14737159.2020.1768849 →
Peer-Reviewed Literature

Petkovich et al. 2011

DOI: 10.1097/MNH.0b013e3283477a7b →
Peer-Reviewed Literature

Ruilope et al. 2023

DOI: 10.1093/eurheartj/ehac683 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

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