Peer-Reviewed Literature Synthesis

Chronic Kidney Disease Biomarker Atlas

Molecular alterations reported in Chronic Kidney Disease compared to healthy controls, from peer-reviewed literature.

Spontaneous remissionGFR decline averages 2-5 mL/min/year on standard care (ACE/ARB + blood pressure control); progression to end-stage…
Best-intervention remissionSGLT2 inhibitors (empagliflozin, dapagliflozin) reduce progression to ESRD by 30-35% in CKD trials (EMPA-KIDNEY…
Gap sizeModerate — SGLT2 inhibitors represent a genuine paradigm shift but are dramatically underused
Primary barrierpractice/access
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Chronic Kidney Disease patients relative to a named comparison population — not inferred.

6
Curated markers
1
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Taglieri et al. 2009

DOI: 10.1373/clinchem.2009.128397 →
Peer-Reviewed Literature

Li et al. 2024

DOI: 10.3389/fendo.2024.1329256 →
Peer-Reviewed Literature

Jamal et al. 2013

DOI: 10.1016/j.jocd.2012.11.012 →
Peer-Reviewed Literature

Benoit et al. 2020

DOI: 10.1080/14737159.2020.1768849 →
Peer-Reviewed Literature

Petkovich et al. 2011

DOI: 10.1097/MNH.0b013e3283477a7b →
Peer-Reviewed Literature

Ruilope et al. 2023

DOI: 10.1093/eurheartj/ehac683 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

Individual Chronic Kidney Disease biomarker pages

Each Chronic Kidney Disease marker has its own page with direction, comparison group, symptoms, test details, citation and FAQ. Browse all marker pages.

Renal

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Chronic Kidney Disease Biomarkers: 6 Blood Tests & Lab Markers. Research Tracker. https://research.opensourcemed.info/chronic-kidney-disease-biomarkers.html (accessed )

Weekly post-viral research digest

New peer-reviewed studies and trial activity across Long COVID, ME/CFS, PACVS, Lyme and Gulf War Illness, every week. Free, no spam.

Subscribe on Substack   Browse the digest archive · RSS