Serum Creatinine in Chronic Kidney Disease

Serum Creatinine is a renal marker reported as elevated in Chronic Kidney Disease when patients are compared with the reference group of the cited comparison (CKD/reduced renal function vs healthy). The source does not tie this marker to a specific symptom cluster, so it is best read as a biological signal rather than a symptom predictor. The evidence summarised here comes from Benoit et al. 2020 and reflects averages across cohorts rather than any single patient's result.

↑ ElevatedRenal

Summary

Direction in Chronic Kidney Disease↑ Elevated — higher than in the comparison group
CategoryRenal
Compared againstCKD/reduced renal function vs healthy
SourceBenoit et al. 2020 — doi:10.1080/14737159.2020.1768849
Condition atlasChronic Kidney Disease Biomarker Atlas

Related Renal markers in Chronic Kidney Disease

Full list: Chronic Kidney Disease Biomarker Atlas.

Frequently asked questions

Is Serum Creatinine high or low in Chronic Kidney Disease?

Elevated. Studies summarised in the OSMF atlas report higher Serum Creatinine in Chronic Kidney Disease than in the reference group of the cited comparison (CKD/reduced renal function vs healthy). Source: Benoit et al. 2020.

Which test measures Serum Creatinine?

The atlas record does not list a standardised clinical test code (LOINC) for Serum Creatinine, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.

Is one abnormal Serum Creatinine result diagnostic of Chronic Kidney Disease?

No. No single biomarker is diagnostic of Chronic Kidney Disease. Serum Creatinine findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Serum Creatinine in Chronic Kidney Disease: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/chronic-kidney-disease/serum-creatinine.html
Get OSMF research updates. New biomarker, trial and treatment evidence summaries by email.
Subscribe on Substack

Last reviewed: 2026-07-03 · Page generated from chronic-kidney-disease.json · Browse: Chronic Kidney Disease atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.