Summary
| Direction in Type 1 Diabetes | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Metabolic |
| Compared against | T1D patients vs healthy (antibody-negative) individuals |
| Source | Mendis et al. 2023 — doi:10.1016/j.bbrep.2022.101413 |
| Condition atlas | Type 1 Diabetes Biomarker Atlas |
Related Metabolic markers in Type 1 Diabetes
Full list: Type 1 Diabetes Biomarker Atlas.
Frequently asked questions
Is IA-2 autoantibodies high or low in Type 1 Diabetes?
Elevated. Studies summarised in the OSMF atlas report higher IA-2 autoantibodies in Type 1 Diabetes than in the reference group of the cited comparison (T1D patients vs healthy (antibody-negative) individuals). Source: Mendis et al. 2023.
Which test measures IA-2 autoantibodies?
The atlas record does not list a standardised clinical test code (LOINC) for IA-2 autoantibodies, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal IA-2 autoantibodies result diagnostic of Type 1 Diabetes?
No. No single biomarker is diagnostic of Type 1 Diabetes. IA-2 autoantibodies findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-07-03 · Page generated from type-1-diabetes.json · Browse: Type 1 Diabetes atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.