Summary
| Direction in Major Depressive Disorder | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Inflammatory |
| Compared against | females with depression vs healthy female controls |
| Test type | Blood test (serum / plasma / whole blood) |
| LOINC code | 1988-5 |
| Source | Jarkas et al. 2024 — doi:10.1016/j.bbi.2024.07.037 |
| Condition atlas | Major Depressive Disorder Biomarker Atlas |
Other conditions where CRP is reported
- CRP in Atrial Fibrillation — ↑ elevated vs AF vs normal population
- CRP in COPD — ↑ elevated vs smokers/COPD vs non-smokers
- C-Reactive Protein (CRP) in Gulf War Illness — ↑ elevated vs HGV
- CRP in Inflammatory Bowel Disease (Crohn's/UC) — ↑ elevated vs active/moderate-to-severe IBD vs symptomatic remission
- C-Reactive Protein (CRP) in Long COVID — ↑ elevated vs HC, R
- CRP in Low Back Pain — ↑ elevated vs nonspecific LBP vs healthy (association evidence)
- C-Reactive Protein (CRP) in Lyme Disease — ↕ inconsistent vs HC
- C-Reactive Protein (CRP) in ME/CFS — ↕ inconsistent vs HC
- CRP in Osteoarthritis — ↑ elevated vs OA vs healthy (elevated but less than RA)
- CRP in Rheumatoid Arthritis — ↑ elevated vs RA vs healthy (acute phase reactant, classification criterion)
See the cross-condition hub: CRP across conditions.
Related Inflammatory markers in Major Depressive Disorder
- IL-6 ↑
Full list: Major Depressive Disorder Biomarker Atlas.
Frequently asked questions
Is CRP high or low in Major Depressive Disorder?
Elevated. Studies summarised in the OSMF atlas report higher CRP in Major Depressive Disorder than in the reference group of the cited comparison (females with depression vs healthy female controls). Source: Jarkas et al. 2024.
Which test measures CRP?
It is measured as a blood test (serum / plasma / whole blood). The standard laboratory code is LOINC 1988-5. Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal CRP result diagnostic of Major Depressive Disorder?
No. No single biomarker is diagnostic of Major Depressive Disorder. CRP findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is CRP specific to Major Depressive Disorder?
No. The same marker is also reported in Atrial Fibrillation, COPD, Gulf War Illness, Inflammatory Bowel Disease (Crohn's/UC), Long COVID, Low Back Pain, Lyme Disease, ME/CFS, Osteoarthritis, Rheumatoid Arthritis in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-07-03 · Page generated from major-depressive-disorder.json · Browse: Major Depressive Disorder atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.