Summary
| Direction in COPD | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Pulmonary |
| Compared against | AATD-associated COPD/emphysema vs normal AAT levels |
| Source | Dasi et al. 2024 — doi:10.1016/j.medcli.2023.10.014 |
| Condition atlas | COPD Biomarker Atlas |
Related Pulmonary markers in COPD
Full list: COPD Biomarker Atlas.
Frequently asked questions
Is Alpha-1 Antitrypsin high or low in COPD?
Reduced. Studies summarised in the OSMF atlas report lower Alpha-1 Antitrypsin in COPD than in the reference group of the cited comparison (AATD-associated COPD/emphysema vs normal AAT levels). Source: Dasi et al. 2024.
Which test measures Alpha-1 Antitrypsin?
The atlas record does not list a standardised clinical test code (LOINC) for Alpha-1 Antitrypsin, which usually means it was measured with research assays or study-specific protocols rather than a routine clinical panel. Check the cited source for the exact method.
Is one abnormal Alpha-1 Antitrypsin result diagnostic of COPD?
No. No single biomarker is diagnostic of COPD. Alpha-1 Antitrypsin findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
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Last reviewed: 2026-07-03 · Page generated from copd.json · Browse: COPD atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.