This is a 3-day study comparing pyridostigmine versus placebo in the treatment of postural tachycardia syndrome (POTS). The researchers expect pyridostigmine to improve tachycardia and stabilize blood pressure.
View on ClinicalTrials.gov ↗Last updated 07 October 2026 from ClinicalTrials.gov. Trial statuses are refreshed automatically; check the registry record for the latest status and contact details.
3 trials2 open to enrolment1 completed
All interventional trials in our ClinicalTrials.gov extract that list Pyridostigmine as an intervention, across Unspecified / Overlap (2), Long COVID / PASC (1), ME/CFS (1). 2 are currently open to enrolment and 1 has completed. Read the OSMF evidence profile for Pyridostigmine for literature, mechanism and dosing context.
Intervention names are normalised from the registry's own arm labels, so the same compound can appear under a brand name, a generic name or a combination; check the full agent index for related entries.
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Recruiting (2)
The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 meeting the Canadian consensus criteria (CCC) for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) as well as having specifically Orthostatic Intolerance (OI).
View on ClinicalTrials.gov ↗Completed (1)
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (\>85%). Among its most troubling symptoms are lightheadedness, fatigue, and decreased memory often called "brain fog" by patients.
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Open Source Medicine Foundation. Pyridostigmine clinical trials for Long COVID, ME/CFS and post-viral illness (3 trials, updated October 2026). Research Tracker, 07 October 2026.
Underlying dataset (JSON, CC BY 4.0):
Open Source Medicine Foundation. Pyridostigmine clinical trials for Long COVID, ME/CFS and post-viral illness (3 trials, updated October 2026). Research Tracker, 07 October 2026.
https://research.opensourcemed.info/trials/by-agent/pyridostigmine.htmlUnderlying dataset (JSON, CC BY 4.0):
https://research.opensourcemed.info/data/clinical_trials/clinical_trials_current.json. Source records: ClinicalTrials.gov.Related: all agents · recruiting Long COVID trials · recruiting ME/CFS trials · open in trial finder.