The purpose of this study IS to * explore the underlying pathophysiology of chronic fatigue syndrome (CFS) in adolescents, particularly focusing on genetics, infections/immunology, endocrinology, autonomic control and cognitions * to assess the effect of clonidine (a drug that attenuates sympathetic nervous activity) in adolescent CFS.
View on ClinicalTrials.gov ↗Last updated 07 October 2026 from ClinicalTrials.gov. Trial statuses are refreshed automatically; check the registry record for the latest status and contact details.
2 trials0 open to enrolment2 completed
All interventional trials in our ClinicalTrials.gov extract that list Clonidine as an intervention, across ME/CFS (2). 0 are currently open to enrolment and 2 have completed. Read the OSMF evidence profile for Clonidine for literature, mechanism and dosing context.
Intervention names are normalised from the registry's own arm labels, so the same compound can appear under a brand name, a generic name or a combination; check the full agent index for related entries.
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Not medical advice. This page is an automatically compiled index of entries on ClinicalTrials.gov. Listing here is not an endorsement of any trial, sponsor or treatment, and trial status can change between our refreshes. Always confirm details on ClinicalTrials.gov and discuss participation with your own clinician.
Completed (2)
The aim of this pilot study for the NorCAPITAL trial is to investigate the feasibility and safety of the drug clonidine in adolescent chronic fatigue syndrome (CFS).
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Open the trial's ClinicalTrials.gov record (the "View on ClinicalTrials.gov" button), read the Eligibility Criteria and Contacts and Locations sections, and contact the study team listed there. Trials only enrol at the sites shown in the record, so check whether a site is near you or whether the study is remote/decentralised. Your own clinician can help you judge whether a trial is a sensible option and may need to provide medical records.
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We summarise newly registered post-viral trials and notable results on the OSMF Substack.
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Open Source Medicine Foundation. Clonidine clinical trials for Long COVID, ME/CFS and post-viral illness (2 trials, updated October 2026). Research Tracker, 07 October 2026.
Underlying dataset (JSON, CC BY 4.0):
Open Source Medicine Foundation. Clonidine clinical trials for Long COVID, ME/CFS and post-viral illness (2 trials, updated October 2026). Research Tracker, 07 October 2026.
https://research.opensourcemed.info/trials/by-agent/clonidine.htmlUnderlying dataset (JSON, CC BY 4.0):
https://research.opensourcemed.info/data/clinical_trials/clinical_trials_current.json. Source records: ClinicalTrials.gov.Related: all agents · recruiting Long COVID trials · recruiting ME/CFS trials · open in trial finder.