📊 OSMF Grading Methodology v1.0

Therapeutic Agent
Evidence Map

Candidate agents for Long COVID, PACVS, ME/CFS, POTS, and MCAS — computationally graded by evidence tier, with linked trial and paper references for every entry.

1,355Unique agents

202Tier 1 (LC RCT)

310Tier 2 (Related RCT)

11,557Source entries

Evidence tiers: T1 — RCT in LC/PASC/PACVS T2 — RCT in related condition T3 — Observational in LC T4 — Case series T5 — Case report T6 — Mechanistic / preclinical

Long COVID / PASC

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

205 agents 201 Tier-1 2 Tier-2

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PACVS

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

2 agents 1 Tier-1 0 Tier-2

Explore PACVS agents →

ME/CFS

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

117 agents 12 Tier-1 105 Tier-2

Explore ME/CFS agents →

POTS / Dysautonomia

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

379 agents 6 Tier-1 157 Tier-2

Explore POTS / Dysautonomia agents →

MCAS

Evidence-graded therapeutic candidates from RCTs, observational studies, and mechanistic literature.

145 agents 0 Tier-1 55 Tier-2

Explore MCAS agents →

Cite this page

Reusing these data? Please cite the tracker so others can find the source.

Open Source Medicine Foundation. (2026). Therapeutic Agent Evidence Map. Research Tracker. https://research.opensourcemed.info/therapeutic-agents.html (accessed )

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New peer-reviewed studies and trial activity across Long COVID, ME/CFS, PACVS, Lyme and Gulf War Illness, every week. Free, no spam.

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OSMF Therapeutic Evidence Grading Methodology v1.0 · ClinicalTrials.gov v2 API & Europe PMC · Pipeline run: 2026-07-02

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