⚠ Provisional — human review required. Tiers are computationally assigned. Per OSMF Grading Methodology §5, every Tier 1/2 entry must be verified against the source paper before publication.
Agent Evidence Map › PACVS
💉 PACVS

Therapeutic Agents
PACVS

Evidence-graded candidate agents from the OSMF discovery pipeline. Click any source count to see linked trial and paper references.

2Agents
1Tier 1 (LC RCT)
0Tier 2 (Related RCT)
24Source entries
Evidence tiers: T1 — RCT in LC/PASC/PACVS T2 — RCT in related condition T3 — Observational in LC T4 — Case series T5 — Case report T6 — Mechanistic / preclinical
2 agents
Japan
T1
T1 — RCT in LC/PASC/PACVS
PACVS
23 sources
  • T6 25483472 ↗ — Tracking the global spread of vaccine sentiments: the global response to Japan's suspension of its H
  • T6INDIRECT 31801180 ↗ — Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis
  • T6INDIRECT 17636779 ↗ — Vaccines for preventing smallpox
  • T6INDIRECT 36229799 ↗ — New-onset and relapsed liver diseases following COVID-19 vaccination: a systematic review
  • T6INDIRECT 38566799 ↗ — Management of infodemics in outbreaks or health crises: a systematic review
  • T6INDIRECT 36162300 ↗ — A systemic review and recommendation for an autopsy approach to death followed the COVID 19 vaccinat
  • T6INDIRECT 40597703 ↗ — Subacute thyroiditis as a post-COVID-19 complication: a systematic review
  • T6INDIRECT 41873447 ↗ — Integrated Clinical and Social Impacts of the COVID-19 Pandemic in Korea: A Combined Systematic and
  • T6INDIRECT 41683343 ↗ — Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome After COVID-19 or Vaccination: A Ran
  • T1 25931793 ↗ — The Immunogenicity and Safety of the Live-attenuated SA 14-14-2 Japanese Encephalitis Vaccine Given
  • T6 36115364 ↗ — Towards prevention of diabetic peripheral neuropathy: clinical presentation, pathogenesis, and new t
  • T6 26636066 ↗ — Vaccines Through Centuries: Major Cornerstones of Global Health
  • T6 23552375 ↗ — GeoSentinel surveillance of illness in returned travelers, 2007-2011
  • T6INDIRECT 33357469 ↗ — Acute flaccid myelitis: cause, diagnosis, and management
  • T6INDIRECT 37626783 ↗ — 'Spikeopathy': COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
  • T6INDIRECT 26433922 ↗ — Enhancing vaccine safety capacity globally: A lifecycle perspective
  • T6INDIRECT 38283029 ↗ — Oral Lichen Planus: An Updated Review of Etiopathogenesis, Clinical Presentation, and Management
  • T6INDIRECT 29702631 ↗ — Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations
  • T6INDIRECT 27679682 ↗ — International Consensus (ICON): allergic reactions to vaccines
  • T6 35436552 ↗ — Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and
  • T6 37945774 ↗ — International Guideline for Idiopathic Inflammatory Myopathy-Associated Cancer Screening: an Interna
  • T6 9018282 ↗ — The complicated task of monitoring vaccine safety
  • T6 21556305 ↗ — No-fault compensation following adverse events attributed to vaccination: a review of international
Tracking the global spread of vaccine sentiments
T6
T6 — Mechanistic / preclinical
PACVS
1 source
  • T6 25483472 ↗ — Tracking the global spread of vaccine sentiments: the global response to Japan's suspension of its H

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Open Source Medicine Foundation. (2026). PACVS Therapeutic Evidence. Research Tracker. https://research.opensourcemed.info/therapeutic-agents-pacvs.html (accessed )

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OSMF Therapeutic Evidence Grading Methodology v1.0 · ClinicalTrials.gov v2 API & Europe PMC · Pipeline run: 2026-07-02

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