Peer-Reviewed Literature Synthesis

Rheumatoid Arthritis Biomarker Atlas

Molecular alterations reported in Rheumatoid Arthritis compared to healthy controls, from peer-reviewed literature.

Spontaneous remission11% achieve drug-free remission (DFR) at median 74 months; most cohorts show 10-15% DFR ceiling
Best-intervention remissionEarly aggressive treat-to-target improves DFR rates modestly; some biologic-era cohorts reach 20-25% DFR; on-drug…
Gap sizeSmall for drug-free remission (biological ceiling is genuinely low); large gap between on-drug remission and drug-free…
Primary barrierbiological (DFR); practice (on-drug remission underachieved due to treatment inertia)
Full remission profile →

Literature Overview

Biomarkers below are included only where peer-reviewed literature explicitly reports the marker's direction in Rheumatoid Arthritis patients relative to a named comparison population — not inferred.

5
Curated markers
2
Categories

Searchable Alterations Database

Comparison populations are quoted as reported in the source literature (e.g. healthy controls, disease-matched patients).

Marker / TestDirectionCategoryvs. ComparisonClinical ContextKey Reference

Key References

Peer-Reviewed Literature

Matuszewska et al. 2016

DOI: 10.5604/17322693.1198270 →
Peer-Reviewed Literature

Kourilovitch et al. 2014

DOI: 10.1016/j.jaut.2014.01.027 →
Peer-Reviewed Literature

Inciarte-Mundo et al. 2022

DOI: 10.3389/fimmu.2022.1001025 →
Peer-Reviewed Literature

Qin et al. 2022

DOI: 10.1136/ard-2022-222605 →
Disclaimer: Educational synthesis of peer-reviewed literature only — not medical advice. Markers are drawn from published disease-vs-comparison-population studies; inclusion here does not imply diagnostic or clinical validation. Consult a qualified healthcare professional for interpretation.

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