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PHOSP-COVID (UK post-hospitalisation COVID-19)
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Design notes & limitations. Large multicentre prospective cohort of hospitalised COVID-19 survivors with an active biobank and deep phenotyping/inflammation profiling. Full recovery was reported by only about a quarter of participants and did not improve meaningfully between 5 months and 1 year. No unexposed comparison group.
Identity & trigger
- Cohort id
phosp-covid- Aliases
- Post-hospitalisation COVID-19 study
- Outbreak / event
- COVID-19 pandemic (UK, 2020-21)
- Pathogen
- SARS-CoV-2 (Virus)
- Exposure ascertainment
- Mixed
Design
- Design
- Prospective (non-inception)
- Denominator defined
- Yes
- Denominator method
- Adults discharged from 39 UK hospitals after confirmed or clinically diagnosed COVID-19 (discharged 5 Mar 2020 - 31 Mar 2021), recruited to a multicentre prospective cohort.
- Recruitment
- hospital
- Time zero
- Hospital discharge following acute COVID-19 (month)
- Control group
- None
Size & attrition
- Enrolled
- 2320
- Analysed / enrolled
- 1965/2320 (85%)
- Max follow-up (months)
- 12
Biospecimens
- Specimens
- Yes
- Types
- serum, plasma, pbmc
- Acute-phase specimens
- No
- Biobank
- active
- External access
- collaboration only
Observations (2)
Functional outcomes
25.5% Proportion
- Measure
- Felt fully recovered func:recovery
- As worded
- “felt fully recovered at 5 months after discharge”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=1965
- Timing
- 5 mo (3-6 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- a2500a08e2 — measure func:recovery · Unclear · ref Not reported · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results (501 of 1965, 25.5% fully recovered at 5 months) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
28.9% Proportion
- Measure
- Felt fully recovered func:recovery
- As worded
- “felt fully recovered at 1 year after discharge”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=804
- Timing
- 12 mo (6-12 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- d2c59c03b3 — measure func:recovery · Unclear · ref Not reported · denom Assessed at timepoint · 6-12 mo · Proportion
- Provenance
- Results (232 of 804, 28.9% fully recovered at 1 year) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Evans RA, McAuley H, Harrison EM, et al. (PHOSP-COVID Collaborative Group) (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. The Lancet Respiratory Medicine. PMID 34627560 · DOI 10.1016/S2213-2600(21)00383-0 primary
- PHOSP-COVID Collaborative Group. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. The Lancet Respiratory Medicine. PMID 35472304 · DOI 10.1016/S2213-2600(22)00127-8
Provenance & verification
- Registration
- ISRCTN10980107
- Funders
- UK Research and Innovation, National Institute for Health Research (NIHR)
- Related cohorts
- none
- Symptom-inventory scope
- Targeted panel
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)