{
  "schema_version": "2.0.0",
  "id": "phosp-covid",
  "name": "PHOSP-COVID (UK post-hospitalisation COVID-19)",
  "aliases": [
    "Post-hospitalisation COVID-19 study"
  ],
  "outbreak_event": "COVID-19 pandemic (UK, 2020-21)",
  "pathogen_id": "sars-cov-2",
  "pathogen_class": "virus",
  "exposure_ascertainment": "mixed",
  "design": "prospective_non_inception",
  "denominator_defined": "yes",
  "denominator_method": "Adults discharged from 39 UK hospitals after confirmed or clinically diagnosed COVID-19 (discharged 5 Mar 2020 - 31 Mar 2021), recruited to a multicentre prospective cohort.",
  "recruitment_source": "hospital",
  "time_zero_definition": "Hospital discharge following acute COVID-19",
  "time_zero_precision": "month",
  "control_group": "none",
  "control_matching_variables": [],
  "n_source_population": null,
  "n_enrolled": 2320,
  "n_analysed": 1965,
  "followups": [
    {
      "months": 5,
      "n_assessed": 1965,
      "n_lost": null
    },
    {
      "months": 12,
      "n_assessed": 804,
      "n_lost": null
    }
  ],
  "max_followup_months": 12,
  "instruments": [
    "sf-36"
  ],
  "case_definition": "not_applicable",
  "pem_assessed": "no",
  "objective_measures": [
    "lab_panel",
    "imaging"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum",
    "plasma",
    "pbmc"
  ],
  "acute_phase_specimens": "no",
  "storage": null,
  "biobank_status": "active",
  "consent_future_use": "broad",
  "external_access": "collaboration_only",
  "contact": null,
  "registration_id": "ISRCTN10980107",
  "funders": [
    "UK Research and Innovation",
    "National Institute for Health Research (NIHR)"
  ],
  "conflicts": null,
  "data_availability": "Access via the PHOSP-COVID consortium data-sharing process.",
  "notes": "Large multicentre prospective cohort of hospitalised COVID-19 survivors with an active biobank and deep phenotyping/inflammation profiling. Full recovery was reported by only about a quarter of participants and did not improve meaningfully between 5 months and 1 year. No unexposed comparison group.",
  "publications": [
    {
      "id": "evans-2021",
      "title": "Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study",
      "authors": "Evans RA, McAuley H, Harrison EM, et al. (PHOSP-COVID Collaborative Group)",
      "year": 2021,
      "journal": "The Lancet Respiratory Medicine",
      "doi": "10.1016/S2213-2600(21)00383-0",
      "pmid": "34627560",
      "url": "https://pubmed.ncbi.nlm.nih.gov/34627560/",
      "open_access": true,
      "is_primary_cohort_paper": true
    },
    {
      "id": "phosp-2022-1yr",
      "title": "Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study",
      "authors": "PHOSP-COVID Collaborative Group.",
      "year": 2022,
      "journal": "The Lancet Respiratory Medicine",
      "doi": "10.1016/S2213-2600(22)00127-8",
      "pmid": "35472304",
      "url": "https://pubmed.ncbi.nlm.nih.gov/35472304/",
      "open_access": true,
      "is_primary_cohort_paper": false
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "observations": [
    {
      "id": "phosp-recovered-5mo",
      "cohort_id": "phosp-covid",
      "publication_id": "phosp-2022-1yr",
      "schema_version": "2.0.0",
      "measure_id": "func:recovery",
      "measure_verbatim": "felt fully recovered at 5 months after discharge",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 1965
      },
      "timing": {
        "timepoint_months": 5,
        "timepoint_band": "3-6mo",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": null,
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": 501,
        "denominator": 1965,
        "percent": 25.5,
        "ci": null,
        "precision": "exact"
      },
      "comparator": {
        "group": "none",
        "value": {
          "status": "not_applicable"
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results (501 of 1965, 25.5% fully recovered at 5 months)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    },
    {
      "id": "phosp-recovered-1yr",
      "cohort_id": "phosp-covid",
      "publication_id": "phosp-2022-1yr",
      "schema_version": "2.0.0",
      "measure_id": "func:recovery",
      "measure_verbatim": "felt fully recovered at 1 year after discharge",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 804
      },
      "timing": {
        "timepoint_months": 12,
        "timepoint_band": "6-12mo",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": null,
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": 232,
        "denominator": 804,
        "percent": 28.9,
        "ci": null,
        "precision": "exact"
      },
      "comparator": {
        "group": "none",
        "value": {
          "status": "not_applicable"
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results (232 of 804, 28.9% fully recovered at 1 year)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    }
  ]
}