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Netherlands Q-fever outbreak cohort (Morroy)
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Design notes & limitations. Large registry-based survey following the world's largest documented Q-fever outbreak, measuring long-term fatigue and quality of life 1-2 years after acute illness with the Nijmegen Clinical Screening Instrument. A denominator-defined bacterial (non-viral) post-infectious fatigue cohort. Cross-sectional postal survey design; compared with population norms rather than a concurrent unexposed control.
Identity & trigger
- Cohort id
morroy-netherlands-qfever- Aliases
- Dutch Q-fever fatigue cohort
- Outbreak / event
- Netherlands Q-fever outbreak 2007-2010
- Pathogen
- Coxiella burnetii (Q fever) (Bacterium)
- Exposure ascertainment
- serology
Design
- Design
- Cross-sectional
- Denominator defined
- Yes
- Denominator method
- Notified acute Q-fever patients from the 2007-2008 Dutch outbreaks, surveyed by postal questionnaire 12-26 months after illness onset; health status compared with Dutch reference norms.
- Recruitment
- population registry
- Time zero
- Onset of notified acute Q-fever illness (month)
- Control group
- None
Size & attrition
- Enrolled
- 870
- Analysed / enrolled
- n/r
- Max follow-up (months)
- 26
Biospecimens
- Specimens
- No
- Types
- none
- Acute-phase specimens
- No
- Biobank
- N/A
- External access
- N/A
Observations (2)
Symptoms
43.5% Proportion
- Measure
- Fatigue sym:fatigue
- As worded
- “severely affected by fatigue 12-26 months after acute Q-fever”
- Population
- whole cohort · denominator Unclear · N=measured, not reported
- Timing
- 18 mo (12-24 mo) · ref Not reported
- Method
- Unclear · Structured symptom questionnaire (author-defined)
- Comparator
- no comparator
- Comparability signature
- 8679aa3234 — measure sym:fatigue · Unclear · ref Not reported · denom Unclear · 12-24 mo · Proportion
- Provenance
- Results/Abstract (fatigue severely affected 43.5%) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Functional outcomes
44.9% Proportion
- Measure
- Impaired quality of life func:qol-impairment
- As worded
- “severely affected general quality of life 12-26 months after acute Q-fever”
- Population
- whole cohort · denominator Unclear · N=measured, not reported
- Timing
- 18 mo (12-24 mo) · ref Not reported
- Method
- Unclear · Structured symptom questionnaire (author-defined)
- Comparator
- no comparator
- Comparability signature
- 0a1c494234 — measure func:qol-impairment · Unclear · ref Not reported · denom Unclear · 12-24 mo · Proportion
- Provenance
- Results/Abstract (general quality of life severely affected 44.9%) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Morroy G, Peters JB, van Nieuwenhof M, et al. (2011). The health status of Q-fever patients after long-term follow-up. BMC Infectious Diseases. PMID 21501483 · DOI 10.1186/1471-2334-11-97 primary
Provenance & verification
- Registration
- n/r
- Funders
- Netherlands National Institute for Public Health and the Environment (RIVM)
- Related cohorts
- none
- Symptom-inventory scope
- Targeted panel
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)