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Chicago adolescent post-mononucleosis cohort (Katz)
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Design notes & limitations. Strong prospective inception cohort in adolescents with laboratory-confirmed acute EBV mononucleosis and structured re-screening for CFS caseness at fixed timepoints. Shows a declining post-infective CFS rate over two years (13% -> 7% -> 4%), one of the cleanest demonstrations of resolving post-viral fatigue.
Identity & trigger
- Cohort id
katz-2009-mononucleosis- Aliases
- Northwestern adolescent IM/CFS cohort
- Outbreak / event
- n/r
- Pathogen
- Epstein-Barr virus (EBV) (Virus)
- Exposure ascertainment
- serology
Design
- Design
- Prospective (inception)
- Denominator defined
- Yes
- Denominator method
- Consecutive adolescents (12-18 y) with serologically confirmed acute infectious mononucleosis, enrolled at diagnosis and followed prospectively.
- Recruitment
- community
- Time zero
- Serologically confirmed acute infectious mononucleosis (month)
- Control group
- None
Size & attrition
- Enrolled
- 301
- Analysed / enrolled
- 301/301 (100%)
- Max follow-up (months)
- 24
Biospecimens
- Specimens
- Yes
- Types
- serum
- Acute-phase specimens
- Yes
- Biobank
- Unknown
- External access
- Unknown
Observations (3)
Case definitions
13% Proportion
- Measure
- Chronic fatigue syndrome / ME-CFS caseness case-def:cfs
- As worded
- “met criteria for chronic fatigue syndrome 6 months after infectious mononucleosis”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=301
- Timing
- 6 mo (3-6 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- 06f8f5f631 — measure case-def:cfs · Unclear · ref Not reported · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results/Abstract (13% at 6 months) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
7% Proportion
- Measure
- Chronic fatigue syndrome / ME-CFS caseness case-def:cfs
- As worded
- “met criteria for chronic fatigue syndrome 12 months after infectious mononucleosis”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=301
- Timing
- 12 mo (6-12 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- d33761e83d — measure case-def:cfs · Unclear · ref Not reported · denom Assessed at timepoint · 6-12 mo · Proportion
- Provenance
- Results/Abstract (7% at 12 months) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
4% Proportion
- Measure
- Chronic fatigue syndrome / ME-CFS caseness case-def:cfs
- As worded
- “met criteria for chronic fatigue syndrome 24 months after infectious mononucleosis”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=301
- Timing
- 24 mo (12-24 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- 6e8b10a7a5 — measure case-def:cfs · Unclear · ref Not reported · denom Assessed at timepoint · 12-24 mo · Proportion
- Provenance
- Results/Abstract (4% at 24 months) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Katz BZ, Shiraishi Y, Mears CJ, Binns HJ, Taylor R. (2009). Chronic fatigue syndrome after infectious mononucleosis in adolescents. Pediatrics. PMID 19564299 · DOI 10.1542/peds.2008-1879 primary
Provenance & verification
- Registration
- n/r
- Funders
- National Institutes of Health (NIAID)
- Related cohorts
- none
- Symptom-inventory scope
- Single domain
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)