Jinyintan (Wuhan) COVID-19 discharge cohort (Huang)

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Design notes & limitations. Large prospective survivor cohort with matched community controls at later timepoints. Integrity caveat: the 6-month paper received a Lancet Expression of Concern (2022) and was retracted and republished (2023) after some variables were found to have been disordered; the principal conclusions were upheld in the republished version and in the 1- and 2-year follow-ups. Retained here with this replication note precisely because the database records integrity status rather than hiding it.

Identity & trigger

Cohort id: huang-2021-wuhan
Aliases: Wuhan 6-month/2-year COVID cohort
Outbreak / event: COVID-19 pandemic (Wuhan first wave, early 2020)
Pathogen: SARS-CoV-2 (Virus)
Exposure ascertainment: pcr

Design

Design: Prospective (non-inception)
Denominator defined: Yes
Denominator method: Consecutive adults with laboratory-confirmed COVID-19 discharged from Jin Yin-tan Hospital, Wuhan, between 7 Jan and 29 May 2020.
Recruitment: hospital
Time zero: Symptom onset of acute COVID-19 (assessed at 6 months, 1 year, and 2 years) (month)
Control group: Unexposed (matched)

Size & attrition

Enrolled: 1733
Analysed / enrolled: 1733/1733 (100%)
Max follow-up (months): 24

Biospecimens

Specimens: Yes
Types: serum
Acute-phase specimens: Unclear
Biobank: Unknown
External access: Unknown

Observations (2)

Symptoms

63% Proportion

Measure: Fatigue sym:fatigue
As worded: “fatigue or muscle weakness at 6 months after symptom onset”
Population: whole cohort · denominator Assessed at timepoint · N=n=1655
Timing: 6 mo (3-6 mo) · ref Not reported
Method: Unclear
Comparator: no comparator
Comparability signature: b4389f13dc — measure sym:fatigue · Unclear · ref Not reported · denom Assessed at timepoint · 3-6 mo · Proportion
Provenance: Results/Abstract (fatigue or muscle weakness 63%, 1038 of 1655) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20

63% Proportion

Measure: Fatigue sym:fatigue
As worded: “fatigue or muscle weakness”
Population: whole cohort · denominator Assessed at timepoint · N=n=1655
Timing: 6 mo (3-6 mo) · ref Current
Method: Structured checklist
Comparator: Unexposed (matched): measured, not reported
Comparability signature: c030cf0354 — measure sym:fatigue · Structured checklist · ref Current · denom Assessed at timepoint · 3-6 mo · Proportion
Provenance: Results (fatigue or muscle weakness 63%, 1038 of 1655) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20

Publications

Huang C, Huang L, Wang Y, et al. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet. PMID 33428867 · DOI 10.1016/S0140-6736(20)32656-8 primary
Huang L, Li X, Gu X, et al. (2022). Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study. The Lancet Respiratory Medicine. PMID 35568052 · DOI 10.1016/S2213-2600(22)00126-6

Provenance & verification

Registration: n/r
Funders: Chinese Academy of Medical Sciences, National Natural Science Foundation of China
Related cohorts: none
Symptom-inventory scope: Targeted panel
Last verified: 2026-07-20 — OSMF research-tracker (web-verified against source)