{
  "schema_version": "2.0.0",
  "id": "huang-2021-wuhan",
  "name": "Jinyintan (Wuhan) COVID-19 discharge cohort (Huang)",
  "aliases": [
    "Wuhan 6-month/2-year COVID cohort"
  ],
  "outbreak_event": "COVID-19 pandemic (Wuhan first wave, early 2020)",
  "pathogen_id": "sars-cov-2",
  "pathogen_class": "virus",
  "exposure_ascertainment": "pcr",
  "design": "prospective_non_inception",
  "denominator_defined": "yes",
  "denominator_method": "Consecutive adults with laboratory-confirmed COVID-19 discharged from Jin Yin-tan Hospital, Wuhan, between 7 Jan and 29 May 2020.",
  "recruitment_source": "hospital",
  "time_zero_definition": "Symptom onset of acute COVID-19 (assessed at 6 months, 1 year, and 2 years)",
  "time_zero_precision": "month",
  "control_group": "unexposed_matched",
  "control_matching_variables": [
    "age",
    "sex",
    "comorbidity"
  ],
  "n_source_population": null,
  "n_enrolled": 1733,
  "n_analysed": 1733,
  "followups": [
    {
      "months": 6,
      "n_assessed": 1733,
      "n_lost": null
    },
    {
      "months": 12,
      "n_assessed": 1276,
      "n_lost": null
    },
    {
      "months": 24,
      "n_assessed": 1192,
      "n_lost": null
    }
  ],
  "max_followup_months": 24,
  "instruments": [
    "sf-36"
  ],
  "case_definition": "not_applicable",
  "pem_assessed": "no",
  "objective_measures": [
    "imaging",
    "lab_panel"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum"
  ],
  "acute_phase_specimens": "unclear",
  "storage": null,
  "biobank_status": "unknown",
  "consent_future_use": "unknown",
  "external_access": "unknown",
  "contact": null,
  "registration_id": null,
  "funders": [
    "Chinese Academy of Medical Sciences",
    "National Natural Science Foundation of China"
  ],
  "conflicts": null,
  "data_availability": null,
  "notes": "Large prospective survivor cohort with matched community controls at later timepoints. Integrity caveat: the 6-month paper received a Lancet Expression of Concern (2022) and was retracted and republished (2023) after some variables were found to have been disordered; the principal conclusions were upheld in the republished version and in the 1- and 2-year follow-ups. Retained here with this replication note precisely because the database records integrity status rather than hiding it.",
  "publications": [
    {
      "id": "huang-2021",
      "title": "6-month consequences of COVID-19 in patients discharged from hospital: a cohort study",
      "authors": "Huang C, Huang L, Wang Y, et al.",
      "year": 2021,
      "journal": "The Lancet",
      "doi": "10.1016/S0140-6736(20)32656-8",
      "pmid": "33428867",
      "url": "https://pubmed.ncbi.nlm.nih.gov/33428867/",
      "open_access": true,
      "is_primary_cohort_paper": true
    },
    {
      "id": "huang-2022-2yr",
      "title": "Health outcomes in people 2 years after surviving hospitalisation with COVID-19: a longitudinal cohort study",
      "authors": "Huang L, Li X, Gu X, et al.",
      "year": 2022,
      "journal": "The Lancet Respiratory Medicine",
      "doi": "10.1016/S2213-2600(22)00126-6",
      "pmid": "35568052",
      "url": "https://pubmed.ncbi.nlm.nih.gov/35568052/",
      "open_access": false,
      "is_primary_cohort_paper": false
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "observations": [
    {
      "id": "huang-fatigue-6mo",
      "cohort_id": "huang-2021-wuhan",
      "publication_id": "huang-2021",
      "schema_version": "2.0.0",
      "measure_id": "sym:fatigue",
      "measure_verbatim": "fatigue or muscle weakness at 6 months after symptom onset",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 1655
      },
      "timing": {
        "timepoint_months": 6,
        "timepoint_band": "3-6mo",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": null,
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": 1038,
        "denominator": 1655,
        "percent": 63,
        "ci": null,
        "precision": "exact"
      },
      "comparator": {
        "group": "none",
        "value": {
          "status": "not_applicable"
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results/Abstract (fatigue or muscle weakness 63%, 1038 of 1655)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    },
    {
      "id": "huang-fatigue-6mo-sf",
      "cohort_id": "huang-2021-wuhan",
      "publication_id": "huang-2021",
      "schema_version": "2.0.0",
      "measure_id": "sym:fatigue",
      "measure_verbatim": "fatigue or muscle weakness",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 1655
      },
      "timing": {
        "timepoint_months": 6,
        "timepoint_band": "3-6mo",
        "reference_period": "current",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "structured_checklist",
        "instrument_id": null,
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": 1038,
        "denominator": 1655,
        "percent": 63,
        "ci": null,
        "precision": "exact"
      },
      "comparator": {
        "group": "unexposed_matched",
        "value": {
          "status": "measured_not_reported"
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results (fatigue or muscle weakness 63%, 1038 of 1655)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    }
  ]
}