← All cohorts · Mixed (EBV / Ross River virus / Coxiella burnetii) cohorts
Dubbo Infection Outcomes Study (DIOS)
source record (JSON) · schema v2.0.0 · CC BY 4.0
Design notes & limitations. Landmark prospective inception cohort showing a stereotyped post-infective fatigue syndrome across three unrelated pathogens, with risk predicted by acute-illness severity rather than the specific microbe. Compared across pathogens; no unexposed control group.
Identity & trigger
- Cohort id
dubbo-infection-outcomes- Aliases
- Dubbo study, DIOS
- Outbreak / event
- n/r
- Pathogen
- Mixed (EBV / Ross River virus / Coxiella burnetii) (Mixed)
- Exposure ascertainment
- serology
Design
- Design
- Prospective (inception)
- Denominator defined
- Yes
- Denominator method
- Consecutive patients presenting to primary care with acute EBV, Ross River virus, or Q fever confirmed by serology, enrolled at acute infection.
- Recruitment
- outpatient clinic
- Time zero
- Onset of acute, serologically confirmed infection (week)
- Control group
- None
Size & attrition
- Enrolled
- 253
- Analysed / enrolled
- 253/253 (100%)
- Max follow-up (months)
- 12
Biospecimens
- Specimens
- Yes
- Types
- serum, whole_blood
- Acute-phase specimens
- Yes
- Biobank
- Unknown
- External access
- Unknown
Observations (1)
Case definitions
11% Proportion
- Measure
- Chronic fatigue syndrome / ME-CFS caseness case-def:cfs
- As worded
- “met diagnostic criteria for a chronic fatigue syndrome at 6 months”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=253
- Timing
- 6 mo (3-6 mo) · ref Not reported
- Method
- Unclear
- Comparator
- no comparator
- Comparability signature
- 06f8f5f631 — measure case-def:cfs · Unclear · ref Not reported · denom Assessed at timepoint · 3-6 mo · Proportion
- Provenance
- Results (approx. 11% met CFS criteria at 6 months) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Hickie I, Davenport T, Wakefield D, et al. (2006). Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. PMID 16950834 · DOI 10.1136/bmj.38933.585764.AE primary
Provenance & verification
- Registration
- n/r
- Funders
- National Health and Medical Research Council (Australia)
- Related cohorts
- none
- Symptom-inventory scope
- Targeted panel
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)