All PAIS cohorts in this database triggered by Mixed (EBV / Ross River virus / Coxiella burnetii). Flags mark evidentiary caveats (preprint, grey literature, patient-reported, uncontrolled, etc.).
| Factor | Contrast | Window | Outcome | Direction | Question | Temporality | Cohort |
|---|---|---|---|---|---|---|---|
| Acute illness severity (composite index) | higher acute illness severity (per unit of the acute symptom-severity score) | Acute phase | Chronic fatigue syndrome / ME-CFS caseness | ↑ increases risk | Conversion (given infection → syndrome) | valid | Dubbo Infection Outcomes Study |
| Age | per year of age | Pre-infection | Chronic fatigue syndrome / ME-CFS caseness | null result | Conversion (given infection → syndrome) | valid | Dubbo Infection Outcomes Study |
| Female sex | female vs male | Genetic / fixed | Chronic fatigue syndrome / ME-CFS caseness | null result | Conversion (given infection → syndrome) | valid | Dubbo Infection Outcomes Study |
| Premorbid psychiatric history | premorbid psychiatric history vs none | Pre-infection | Chronic fatigue syndrome / ME-CFS caseness | null result | Conversion (given infection → syndrome) | valid | Dubbo Infection Outcomes Study |
| Infecting pathogen (which agent) | EBV vs Ross River virus vs Coxiella burnetii | Acute phase | Chronic fatigue syndrome / ME-CFS caseness | null result | Conversion (given infection → syndrome) | valid | Dubbo Infection Outcomes Study |
| Acute cytokine levels (IL-6/IL-1β/IFN-γ/TNF-α/IL-10) | higher acute cytokine levels | Acute phase | Chronic fatigue syndrome / ME-CFS caseness | null result | Conversion (given infection → syndrome) | valid | Dubbo Infection Outcomes Study |