Disease × agent pairs

Major Depressive Disorder: candidate agents with evidence

25 agents linked to Major Depressive Disorder by at least one registered trial or two publications, ranked by the OSMF evidence score. Not treatment advice.

Research Tracker › Pairs › Major Depressive Disorder

Agomelatine

Drug · tier A · 8 trials (0 recruiting) · 14 publications · score 80.0

Brexpiprazole

Drug · tier A · 8 trials (1 recruiting) · 15 publications · score 80.0

Citalopram

Drug · tier A · 8 trials (2 recruiting) · 15 publications · score 80.0

Escitalopram

Drug · tier A · 8 trials (2 recruiting) · 16 publications · score 80.0

Paroxetine

Drug · tier A · 8 trials (0 recruiting) · 14 publications · score 79.5

Mirtazapine

Drug · tier A · 8 trials (1 recruiting) · 14 publications · score 75.0

Clomipramine

Drug · tier A · 5 trials (0 recruiting) · 15 publications · score 62.5

Amphetamine

Drug · tier A · 8 trials (1 recruiting) · 4 publications · score 60.0

Escitalopram Oxalate

Drug · tier A · 8 trials (2 recruiting) · 5 publications · score 60.0

Psilocybin

Drug · tier C · 8 trials (1 recruiting) · 16 publications · score 60.0

Quetiapine Fumarate

Drug · tier A · 8 trials (0 recruiting) · 5 publications · score 60.0

Sertraline Hydrochloride

Drug · tier A · 8 trials (3 recruiting) · 5 publications · score 60.0

Duloxetine Hydrochloride

Drug · tier A · 8 trials (0 recruiting) · 4 publications · score 59.0

Bupropion Hydrochloride

Drug · tier A · 8 trials (2 recruiting) · 4 publications · score 58.0

Mecamylamine

Drug · tier A · 8 trials (0 recruiting) · 3 publications · score 56.0

Citalopram Hydrobromide

Drug · tier A · 8 trials (0 recruiting) · 4 publications · score 55.5

Vitamin D

Supplement · tier C · 7 trials (2 recruiting) · 11 publications · score 52.5

Trazodone Hydrochloride

Drug · tier A · 8 trials (2 recruiting) · 1 publications · score 46.5

Curcumin

Supplement · tier C · 2 trials (0 recruiting) · 8 publications · score 33.0

Omega-3 fatty acids (EPA/DHA)

Supplement · tier C · 8 trials (1 recruiting) · 0 publications · score 31.0

Levomilnacipran Hydrochloride

Drug · tier A · 3 trials (0 recruiting) · 0 publications · score 30.0

Magnesium

Supplement · tier C · 8 trials (1 recruiting) · 1 publications · score 30.0

Saffron (Crocus sativus)

Supplement · tier C · 0 trials (0 recruiting) · 6 publications · score 20.0

St. John's Wort (Hypericum perforatum)

Supplement · tier C · 4 trials (0 recruiting) · 1 publications · score 20.0

SAMe (S-adenosylmethionine)

Supplement · tier C · 4 trials (0 recruiting) · 0 publications · score 17.0

Research map, not treatment advice. Built 2026-10-07.