Summary
Concurrent Training is tracked by OSMF as an investigational option for Long COVID; no regulator has approved it for this indication, and most post-viral conditions have no approved disease-modifying therapy at all. ClinicalTrials.gov lists 1 registered trial linking Concurrent Training to Long COVID: 1 has completed. None of the registered studies carries a drug-development phase label, which is typical for behavioural, device and supplement protocols. It plans or enrolled 66 participants. Registered activity dates to 2022. The literature layer holds 15 publications for this pair: 3 clinical trial publications, 11 PubMed search records and 1 other publication. Publication years run from 2017 to 2025. These are primary trial reports rather than syntheses, so results have not yet been pooled or graded independently.
Long COVID / PASC is tracked on the OSMF post-viral programme alongside ME/CFS, Long COVID, POTS and MCAS. Across the programme, 423 candidate agents are logged for Long COVID, most of them preliminary; this page isolates the record for one of them.
Evidence table
| Evidence tier | C · Preliminary |
|---|---|
| Evidence score | 25.5 (trials 2.5, literature 18.0, tier 5, approved bonus 0.0) |
| Registered trials | 1 total: 0 recruiting, 0 active / not yet recruiting, 1 completed, 0 other |
| Linked publications | 15 (11 PubMed search records, 3 clinical trial publications, 1 other publication) |
| Agent type | Behavioural (Behavioral / Protocol / Exercise) |
| Development stage (any indication) | Investigational |
| Mechanism / class | Not recorded |
| Data sources | OSMF therapeutic agent database, ClinicalTrials.gov, PubMed |
How the evidence score is calculated
- Each registered trial scores by status (recruiting / active / enrolling 3, completed 2.5, not yet recruiting 2, unknown 1, terminated / withdrawn / suspended 0.5) plus a phase bonus (phase 3-4 +2, phase 2 +1, phase 1 +0.5). The trial component is capped at 30.
- Each literature item scores by design (Cochrane review 5, meta-analysis 4, systematic review 3, RCT 3, clinical trial publication 2, curated reference 1.5, other PubMed record 1). The literature component is capped at 30.
- The existing evidence tier adds 15 (A / Strong), 10 (B / Moderate), 5 (C / Preliminary) or 0 (D / Anecdotal).
- Agents approved for any indication (max clinical phase 4) add 5, because an approved agent has an established safety profile that lowers the barrier to repurposing trials.
- The score ranks what has been studied, not what works. It does not read effect sizes or directions of effect.
Registered clinical trials
| NCT ID | Title | Status | Phase | Enrolment |
|---|---|---|---|---|
| NCT05204511 | Exercise and Post-COVID/ Long-COVID: Effects of Different Training Modalities on Various Parameters in People Affected by the Sequelae of CO University of Vienna · 2022 | completed | Not applicable | 66 |
Published literature
- PubMed record (biomarker-intervention search) Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes.Nutrients · 2025 · PMID 41228432
- PubMed record (biomarker-intervention search) Low-grade systemic inflammation biomarkers in sedentary young healthy adults are not significantly affected by a 24-week concurrent training intervention.Annals of the New York Academy of Sciences · 2025 · PMID 40219791
- PubMed record (biomarker-intervention search) Effect of Concurrent Exercise Training on Stress, Depression and Anxiety in Inactive Academics: Secondary Analysis of a Randomized Controlled Trial.Research quarterly for exercise and sport · 2025 · PMID 40067213
- PubMed record (biomarker-intervention search) Enhancing Muscle Strength and Reducing Inflammation: The Combined Effects of Hydrolyzed House Cricket Protein Supplementation and Concurrent Training in Older Women.Food science & nutrition · 2025 · PMID 40994451
- PubMed record (biomarker-intervention search) The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial.Antioxidants (Basel, Switzerland) · 2024 · PMID 39594432
- PubMed record (biomarker-intervention search) Reduction in systemic muscle stress markers after exercise-induced muscle damage following concurrent training and supplementation with specific collagen peptides - a randomized controlled trial.Frontiers in nutrition · 2024 · PMID 38590831
- PubMed record (biomarker-intervention search) The impacts of exercise interventions on inflammaging markers in overweight/obesity patients with heart failure: A systematic review and meta-analysis of randomized controlled trials.International journal of cardiology. Heart & vasculature · 2023 · PMID 37416483
- PubMed record (biomarker-intervention search) Synergistic Effects of Combined Concurrent Training and Eri-Polyunsaturated Fatty Acid Supplementation on Bone Mineral Density, Muscle Strength, and Inflammation.Preventive nutrition and food science · 2023 · PMID 37066034
- PubMed record (biomarker-intervention search) Impacts of Exercise Interventions on Inflammatory Markers and Vascular Adhesion Molecules in Patients With Heart Failure: A Meta-analysis of RCTs.CJC open · 2023 · PMID 37397615
- PubMed record (biomarker-intervention search) Concurrent Training with Blood Flow Restriction does not Decrease Inflammatory Markers.International journal of sports medicine · 2018 · PMID 29121681
- PubMed record (biomarker-intervention search) Modulation of inflammatory response arising from high-intensity intermittent and concurrent strength training in physically active males.Cytokine · 2017 · PMID 28043028
- Clinical trial publication (PubMed validation search) PubMed record PMID 39665835
- Clinical trial publication (PubMed validation search) PubMed record PMID 36476156
- Clinical trial publication (PubMed validation search) PubMed record PMID 36111386
- Review (PubMed validation search) PubMed record PMID 37841213
Mechanism and notes
This is a behavioural, rehabilitation or protocol-based intervention rather than a molecule, so no pharmacological mechanism is recorded.
Clinical notes: Investigational for listed conditions. 1 associated trial(s) and 0 study reference(s) in current data. Review primary sources and consult specialists before use.
Safety: Limited specific safety data in these populations. Review full prescribing information and consult specialist. Many agents used off-label or investigational.
Dosing in studies: See linked studies/trials for reported doses and durations; typical protocols vary widely.
Frequently asked questions
Is Concurrent Training approved for Long COVID?
Concurrent Training is tracked by OSMF as an investigational option for Long COVID; no regulator has approved it for this indication, and most post-viral conditions have no approved disease-modifying therapy at all. Approval status for the specific indication should always be confirmed with the relevant regulator and prescribing information.
Is Concurrent Training in clinical trials for Long COVID?
ClinicalTrials.gov lists 1 registered trial linking Concurrent Training to Long COVID: 1 has completed. None of the registered studies carries a drug-development phase label, which is typical for behavioural, device and supplement protocols. It plans or enrolled 66 participants. Registered activity dates to 2022.
What does the evidence show for Concurrent Training in Long COVID?
Concurrent Training has 1 completed trial and 15 linked publications for Long COVID. Completed trials may or may not have posted results; follow the NCT links to check. OSMF's existing evidence tier for this pair is C (Preliminary), taken from the OSMF therapeutic agent database, which grades agents by the volume and design of condition-specific evidence rather than by effect size.
Cite this page
Data: ClinicalTrials.gov, PubMed, Open Targets, ChEMBL, DGIdb and the OSMF therapeutic agent database. Last updated 2026-10-07. Page built 2026-10-07.