Summary
Angiotensin Converting Enzyme Inhibitor is tracked by OSMF as an investigational option for Long COVID; no regulator has approved it for this indication, and most post-viral conditions have no approved disease-modifying therapy at all. ClinicalTrials.gov lists 1 registered trial linking Angiotensin Converting Enzyme Inhibitor to Long COVID: 1 has completed. The most advanced is Phase 3 (NCT04591210, sponsored by Ottawa Heart Institute Research Corporation). It plans or enrolled 372 participants. Registered activity dates to 2021. The literature layer holds 1 publication for this pair: 1 other publication. Items here are search-derived or curated references rather than classified trial reports; treat them as leads to read, not as graded evidence.
Long COVID / PASC is tracked on the OSMF post-viral programme alongside ME/CFS, Long COVID, POTS and MCAS. Across the programme, 423 candidate agents are logged for Long COVID, most of them preliminary; this page isolates the record for one of them.
Evidence table
| Evidence tier | B · Moderate |
|---|---|
| Evidence score | 15.5 (trials 4.5, literature 1.0, tier 10, approved bonus 0.0) |
| Registered trials | 1 total: 0 recruiting, 0 active / not yet recruiting, 1 completed, 0 other |
| Linked publications | 1 (1 other publication) |
| Agent type | Other (Other / Unclassified) |
| Development stage (any indication) | Investigational |
| Mechanism / class | Not recorded |
| Data sources | OSMF therapeutic agent database, ClinicalTrials.gov, PubMed |
How the evidence score is calculated
- Each registered trial scores by status (recruiting / active / enrolling 3, completed 2.5, not yet recruiting 2, unknown 1, terminated / withdrawn / suspended 0.5) plus a phase bonus (phase 3-4 +2, phase 2 +1, phase 1 +0.5). The trial component is capped at 30.
- Each literature item scores by design (Cochrane review 5, meta-analysis 4, systematic review 3, RCT 3, clinical trial publication 2, curated reference 1.5, other PubMed record 1). The literature component is capped at 30.
- The existing evidence tier adds 15 (A / Strong), 10 (B / Moderate), 5 (C / Preliminary) or 0 (D / Anecdotal).
- Agents approved for any indication (max clinical phase 4) add 5, because an approved agent has an established safety profile that lowers the barrier to repurposing trials.
- The score ranks what has been studied, not what works. It does not read effect sizes or directions of effect.
Registered clinical trials
| NCT ID | Title | Status | Phase | Enrolment |
|---|---|---|---|---|
| NCT04591210 | The COVID-RASi Trial (COVID-19) Ottawa Heart Institute Research Corporation · 2021 | completed | Phase 3 | 372 |
Published literature
- Case series (PubMed validation search) PubMed record PMID 34100519
Mechanism and notes
No mechanism of action is recorded for this pair in the source databases.
Clinical notes: Investigational for listed conditions. 1 associated trial(s) and 0 study reference(s) in current data. Review primary sources and consult specialists before use.
Safety: Limited specific safety data in these populations. Review full prescribing information and consult specialist. Many agents used off-label or investigational.
Dosing in studies: See linked studies/trials for reported doses and durations; typical protocols vary widely.
Frequently asked questions
Is Angiotensin Converting Enzyme Inhibitor approved for Long COVID?
Angiotensin Converting Enzyme Inhibitor is tracked by OSMF as an investigational option for Long COVID; no regulator has approved it for this indication, and most post-viral conditions have no approved disease-modifying therapy at all. Approval status for the specific indication should always be confirmed with the relevant regulator and prescribing information.
Is Angiotensin Converting Enzyme Inhibitor in clinical trials for Long COVID?
ClinicalTrials.gov lists 1 registered trial linking Angiotensin Converting Enzyme Inhibitor to Long COVID: 1 has completed. The most advanced is Phase 3 (NCT04591210, sponsored by Ottawa Heart Institute Research Corporation). It plans or enrolled 372 participants. Registered activity dates to 2021.
What does the evidence show for Angiotensin Converting Enzyme Inhibitor in Long COVID?
Angiotensin Converting Enzyme Inhibitor has 1 completed trial and 1 linked publication for Long COVID. Completed trials may or may not have posted results; follow the NCT links to check. OSMF's existing evidence tier for this pair is B (Moderate), taken from the OSMF therapeutic agent database, which grades agents by the volume and design of condition-specific evidence rather than by effect size.
Cite this page
Data: ClinicalTrials.gov, PubMed, Open Targets, ChEMBL, DGIdb and the OSMF therapeutic agent database. Last updated 2026-10-07. Page built 2026-10-07.