Measles — RepurpOS | OpenSourceMedicine

Disease overview

Alterations

Molecular (A)

Clinical (B–E)

Direct drugs

Via biomarker

Natural agents

Natural products

Merged ranked

With trial/literature evidence

Sources: Open Targets, HPO, ClinicalTrials.gov, ChEMBL, OSMF Chronic Disease Review, PubMed MeSH, PubMed Literature, PubMed NP · Pipeline phase 7 · Updated 2026-07-05

Identifiers: MONDO: MONDO:0005850 · MESH: D008457 · UMLS_CUI: C0025007

Alterations

24 total · Types A (molecular) through E (functional)

Name	Type	Subtype	Direction	Frequency	Evidence	Sources	Links
Lymphadenopathy	Pathology	Pathological finding	—	—	Moderate	HPO, Monarch	HPO
Antibody titres	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Concentrations of Anti-circumsporozoite Protein (Anti-CS) Antibodies.	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Concentrations of Antibodies Against Hepatitis B (Anti-HB Antibodies).	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Growth	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Microscopy assessment of the infectious activity of the measles vaccine virus presented in breast milk in at least one sample.	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Morbidity	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Mortality	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of Participants With Postvaccination Mumps ELISA Antibody Titer ≥10 Ab Units/mL	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of Participants With Postvaccination Rubella ELISA Antibody Titer ≥10 IU/mL	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of Participants With Unsolicited AEs	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of Subjects With Anti-hepatitis A Virus (HAV) Antibody Concentration Equal or Above the Cut-off Value in HAV and HAV+MMR+V Groups	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of Subjects With Serious Adverse Events (SAEs).	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of Subjects With Unsolicited Adverse Events (AEs)	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of infants with reported clinical symptoms of measles	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of women with positive RT-PCR for measles vaccine virus strain in urine in at least one sample	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Number of women with reported clinical symptoms of measles	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Phase A: Number of Subjects Reporting Fever	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Prevalence of the measles vaccine virus strain in breast milk.	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Proportion of participants with protective antibodies to measles, mumps, and rubella	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
Quantification of the measles vaccine virus strain presented in breast milk in at least one sample	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
The geometric means of anti-measles IgG level	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
The geometric means of anti-mumps IgG titers	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—
The geometric means of anti-rubella IgG level	Lab / Clinical	Lab value	—	—	Emerging	ClinicalTrials.gov	—

Therapeutics

Direct disease associations, biomarker-linked drugs, OSMF narrative-review natural agents, and merged ranking. Only agents with registry trials or published clinical literature are shown by default.

From opensourcemed.info/chronic-disease — Acute management of measles: a systematic review of therapeutic strategies. Candidates for further study, not approved treatments.

Show agents without direct trial evidence

Drug	Type	Phase	Evidence	Score	Price (UK / US)	Trials & literature	Sources	Links
CHEMBL6068354	Small molecule	Approved	Strong	100	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL22	Small molecule	Phase III	Moderate	80	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL443	Small molecule	Phase III	Moderate	80	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL2109201	Small molecule	Phase II	Emerging	60	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL2109211	Small molecule	Phase II	Emerging	60	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL2109225	Small molecule	Phase II	Emerging	60	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
Interferon-alpha (Interferon-α) OSMF review	Biologic	Preclinical	Emerging	30	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Investigational monoclonal antibodies OSMF review	Biologic	Preclinical	Emerging	30	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Ribavirin OSMF review	Small molecule	Preclinical	Emerging	30	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	5 Trial pubs 1 RCT View evidence Published literature Systematic review Acute management of measles: A systematic review of therapeutic strategies (Antiviral research, 2026) Clinical trial publication Effects of ribavirin on measles (Journal of the Indian Medical Association, 2011) Clinical trial publication Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis (Antimicrobial agents and chemotherapy, 2004) Clinical trial publication Biochemistry and clinical applications of ribavirin (Antimicrobial agents and chemotherapy, 1986) Clinical trial publication Ribavirin: a clinical overview (European journal of epidemiology, 1986) Clinical trial publication A double-blind, placebo-controlled evaluation of ribavirin in the treatment of acute measles (Clinical therapeutics, 1981) CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Vitamin A (High-dose supplementation) OSMF review	Supplement	Preclinical	Emerging	30	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Zinc supplementation OSMF review	Supplement	Preclinical	Emerging	30	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	2 Cochrane 1 Meta-analysis 1 Trial pubs 1 RCT View evidence Published literature Cochrane review Zinc supplementation for the treatment of measles in children (The Cochrane database of systematic reviews, 2017) Cochrane review Zinc supplementation for the treatment of measles in children (The Cochrane database of systematic reviews, 2015) Meta-analysis Interventions for High-Burden Infectious Diseases in Children and Adolescents: A Meta-analysis (Pediatrics, 2022) Clinical trial publication Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial (The American journal of clinical nutrition, 2002) CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation

Drug	Type	Phase	Evidence	Score	Price (UK / US)	Trials & literature	Sources	Links
CHEMBL6068354	Small molecule	Approved	Strong	100	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL22	Small molecule	Phase III	Moderate	80	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL443	Small molecule	Phase III	Moderate	80	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL2109201	Small molecule	Phase II	Emerging	60	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL2109211	Small molecule	Phase II	Emerging	60	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets
CHEMBL2109225	Small molecule	Phase II	Emerging	60	Varies — check openprescribing.net (UK) or costplusdrugs.com / GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ChEMBL	ChEMBL Open Targets

No therapeutics in this section.

Drug	Type	Phase	Evidence	Score	Price (UK / US)	Trials & literature	Sources	Links
Interferon-alpha (Interferon-α) OSMF review	Biologic	Preclinical	Emerging	30	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Investigational monoclonal antibodies OSMF review	Biologic	Preclinical	Emerging	30	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Ribavirin OSMF review	Small molecule	Preclinical	Emerging	30	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	5 Trial pubs 1 RCT View evidence Published literature Systematic review Acute management of measles: A systematic review of therapeutic strategies (Antiviral research, 2026) Clinical trial publication Effects of ribavirin on measles (Journal of the Indian Medical Association, 2011) Clinical trial publication Pharmacokinetics and effects of ribavirin following intraventricular administration for treatment of subacute sclerosing panencephalitis (Antimicrobial agents and chemotherapy, 2004) Clinical trial publication Biochemistry and clinical applications of ribavirin (Antimicrobial agents and chemotherapy, 1986) Clinical trial publication Ribavirin: a clinical overview (European journal of epidemiology, 1986) Clinical trial publication A double-blind, placebo-controlled evaluation of ribavirin in the treatment of acute measles (Clinical therapeutics, 1981) CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Vitamin A (High-dose supplementation) OSMF review	Supplement	Preclinical	Emerging	30	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation
Zinc supplementation OSMF review	Supplement	Preclinical	Emerging	30	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	2 Cochrane 1 Meta-analysis 1 Trial pubs 1 RCT View evidence Published literature Cochrane review Zinc supplementation for the treatment of measles in children (The Cochrane database of systematic reviews, 2017) Cochrane review Zinc supplementation for the treatment of measles in children (The Cochrane database of systematic reviews, 2015) Meta-analysis Interventions for High-Burden Infectious Diseases in Children and Adolescents: A Meta-analysis (Pediatrics, 2022) Clinical trial publication Zinc supplementation as adjunct therapy in children with measles accompanied by pneumonia: a double-blind, randomized controlled trial (The American journal of clinical nutrition, 2002) CT.gov search · Cochrane · PubMed	OSMF Chronic Disease Review	OSMF Review Citation

Natural Products

11 natural products with the same evidence schema as repurposed drugs — registry trials, PubMed literature, and reference links (pipeline-ranked). Only agents with direct clinical evidence are shown by default.

Reference lookups: Examine.com

Show agents without direct trial evidence

Drug	Type	Phase	Evidence	Score	Price (UK / US)	Trials & literature	Sources	Links
Spirulina Natural product In Vitro Study Calcium spirulan, an inhibitor of enveloped virus replication, from a b…	Nutraceutical	Preclinical	Emerging	7	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		—
Ginkgo Biloba Natural product In Vitro Study Ginkgolic acid inhibits fusion of enveloped viruses.	Botanical	Preclinical	Emerging	2	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		—
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol Natural product	Food compound	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed	ClinicalTrials.gov	PubChem
Vitamin a Natural product Human Study Children with measles studied in this New York City outbreak had lower… Human Study Ribavirin and high dose vitamin A might be a treatment option for measl… Human Study Vitamin A supplementation may have therapeutic activity in the treatmen…	Food compound	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		PubChem
Seaweed Natural product Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds a…	Nutraceutical	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	1 pubs View evidence CT.gov search · Cochrane · PubMed		—
Infection/Infectitious Agent Byproducts (Beneficial) Natural product Human Study Laboratory characterization of measles virus infection in previously va… Human Study Measles and mumps, especially in case of both infections, were associat… Human Study Measles infection protects against allergic disease in children.	Nutraceutical	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		—
Beta-Carotene Natural product Cochrane review Vitamin A supplementation for preventing morbidity and mortality in chi… Cochrane review Vitamin A supplementation for preventing morbidity and mortality in chi… Cochrane review Vitamin A supplements for preventing mortality, illness, and blindness…	Nutraceutical	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	4 Cochrane 4 Meta-analysis 1 Trial pubs View evidence Published literature Cochrane review Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age (The Cochrane database of systematic reviews, 2022) Cochrane review Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age (The Cochrane database of systematic reviews, 2017) Cochrane review Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis (BMJ (Clinical research ed.), 2011) Cochrane review Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age (The Cochrane database of systematic reviews, 2010) Clinical trial publication Oxidant and non-enzymatic antioxidant status in measles (Journal of tropical pediatrics, 2007) CT.gov search · Cochrane · PubMed		—
Anthocyanins Natural product In Vitro Study A defined anthocyanin mixture sourced from bilberry and black currant i…	Food compound	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		PubChem
Bilberry Natural product In Vitro Study A defined anthocyanin mixture sourced from bilberry and black currant i…	Nutraceutical	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		—
Black Currant Natural product In Vitro Study A defined anthocyanin mixture sourced from bilberry and black currant i…	Nutraceutical	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		—
Polyphenols Natural product	Nutraceutical	Preclinical	Emerging	0	Varies — openprescribing.net (UK) / costplusdrugs.com or GoodRx (US)	No indexed hits View evidence CT.gov search · Cochrane · PubMed		—

Alterations and therapeutics are aggregated from public databases (Open Targets, HPO, ChEMBL, DGIdb, and others). Natural agents are candidates from OSMF narrative reviews on opensourcemed.info/chronic-disease.html — not approved treatments. This page is for research orientation only — not medical advice.