29 June 2026 – 5 July 2026 · published 5 July 2026 · Subscribe
Between 29 June 2026 and 5 July 2026 the tracker indexed 90 new peer-reviewed studies and 0 clinical-trial updates across 8 post-viral and post-infectious conditions.
Studies tracked = entries across the 8 condition feeds (each feed keeps a rolling window of recent PubMed results); trials tracked = ClinicalTrials.gov records in the current trial snapshot (last run 2026-06-26); biomarkers catalogued = marker entries across all OSMF biomarker atlases.
Full feed: Long COVID research tracker
Following the acute phase of a SARS-CoV-2 infection, post-COVID - or long-COVID - syndrome may develop. This condition is characterized by unpleasant, persistent or new-onset symptoms following the acute phase of the infection.
No abstract available.
This study examined the long-term effects of polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA and Toll-like receptor 3 (TLR3) agonist, on behavioral and immune outcomes in chronically stressed mice. Male C57BL/6J mice were exposed to 21 days of wet bedding stress followed by a poly I:C injection.
No abstract available.
Studies of Long COVID or Post-COVID-19 condition in children and young people have varied considerably in their reported prevalences. We aimed to examine the methodological heterogeneity underlying this variability and explore whether methodological characteristics were correlated with reported Long COVID outcome prevalence, in order to inform recommendations to improve reporting in future pandemic-related...
The impact of long-COVID can be substantial for individuals, health systems and the economy, nevertheless, treatment and support options are limited. Yoga offers a potential solution to reduce the burden of long-COVID, demonstrating positive impacts on the biological mechanisms implicated in long-COVID, key long-COVID symptoms and associated mental health challenges.
BackgroundCoronary artery dilatation (CAD) in neonates is an uncommon but clinically important finding on echocardiography. Reported associations include multisystem inflammatory syndrome in the newborn (MIS-N) following COVID-19 infection, congenital cardiac malformations, and perinatal inflammatory states.
Light is a major environmental factor regulating circadian rhythms, sleep- wake cycles, and mood-related behaviors. Patients with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often experience circadian disruption and poor sleep quality, which severely compromise their quality of life; however, the relationship between light exposure and illness severity remains largely unknown.
This study sorted out the clinical outcome of traditional Chinese and western medicines in the treatment of long COVID to lay the foundation for the construction of a core indicator set. Search was made on some databases and platforms from their inception to December 2024, which included eight databases of CNKI, Wanfang, SinoMed, VIP, PubMed, Cochrane Library, EMbase, and Web of Science and three clinical research...
Post-infectious syndromes including post-treatment Lyme disease syndrome (PTLDS), long COVID, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and pediatric acute-onset neuropsychiatric syndrome (PANS)/pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) share overlapping clinical phenotypes characterized by fatigue, cognitive dysfunction, sleep disturbance...
Long COVID (LC/PASC) and Fibromyalgia (FM) share prominent pain, fatigue, and cognitive symptoms and are often difficult to distinguish clinically. The authors compared LC/PASC and FM using harmonized questionnaires assessing symptoms, function, and medication burden to quantify phenotype overlap and inform biomarker development.
Inflammation and lung damage in response to respiratory viral infection is a major cause of morbidity and mortality. How specialized lung alveolar structures contribute to variation in inflammatory lung damage observed in patients is a gap in current knowledge.
The high prevalence of long COVID globally necessitates investigation into its self-management, especially given the absence of definitive and effective treatments and uneven access to healthcare services. This study surveyed the use of over-the-counter (OTC) medicines, supplements, remedies, and other non-prescription therapies for managing long COVID symptoms in the UK.
No abstract available.
The global research has actively investigated the post-COVID neuropsychiatric symptoms (PCNS). There is a paucity of studies from India that explore long-term PCNS.
This study aimed to examine the knowledge, attitude, and perception of body donation among Phase-1 medical students at our institution. The objectives were to assist teachers in providing insight into the perception of this among students.
A variant in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) was reported to be related to metabolic-associated fatty liver disease. However, the mechanism by which this variant leads to liver fibrosis has not been unveiled yet.
Post-COVID-19 syndrome encompasses persistent cognitive, neurological, and psychiatric symptoms following SARS-CoV-2 infection, profoundly affecting global quality of life. Clarifying the neurobiological basis of these symptoms is vital for effective therapeutic interventions.
Long COVID is known to be associated with prolonged multiple organ symptoms and decreased health-related quality of life (HRQoL), but the pathogenesis and relationship between immune, inflammatory, and metabolic biomarkers and HRQoL remains poorly understood. This systematic review aims to synthesize the evidence on the health-related quality of life of patients with Long COVID and to summarize the reported...
Cancer-associated fibroblasts (CAFs) are key cell types within the tumor microenvironment (TME), responsible for their pro-tumorigenic effects and metastasis. Specifically, inflammatory CAFs (iCAFs), a CAF subtype, are known to induce tumor cell progression, migration, and immunosuppression.
Low health literacy is common among surgical patients, with few interventions addressing this problem. A patient safety checklist (PASC) was developed to involve elective surgical patients in optimising health and safety before and after surgery.
Liver fibrosis constitutes a central pathological hallmark of advanced chronic liver diseases. However, effective therapeutic targets and pharmacological interventions remain insufficiently defined.
Post-Covid syndrome remains a major clinical challenge due to the lack of specific biomarkers and reliance on exclusion criteria. Routine laboratory data offers potential for identifying biological signatures, but their use in machine learning is hampered by data quality issues.
Lactic acid bacteria are commonly used to convert carbohydrates into valuable products like lactic acid, but they currently rely on carbon sources from food crops, raising sustainability and cost concerns. Lignocellulosic waste is a more sustainable alternative, yet these bacteria cannot naturally break down cellulose to grow on it.
Pancreatic adenosquamous carcinoma (PASC) is a rare and aggressive malignancy with poorer prognosis than pancreatic ductal adenocarcinoma (PDAC). This study aimed to identify distinctive endoscopic ultrasound (EUS) features for pre-operative differentiation between PASC and PDAC.
No abstract available.
Characterize the long-term vocal outcomes of patients who required ICU care for COVID-19 infection. Prospective cohort study.
Following the end of the COVID-19 pandemic, attention shifted towards patients who developed sequelae, persistent symptoms, or relapsing or remitting symptoms of new conditions after a prior history of acute SARS-CoV-2 infection. The objective of the present study was to identify the prevalence, clinical characteristics, and potential associated factors of long COVID in children treated during the pandemic in a...
Bacteria and viruses' potential collaboration has been reported to result in enhanced infection pathogenesis. New antimicrobial agents are necessary, but stronger synthetic antibiotics cause more severe side effects.
The coronavirus disease (COVID-19) pandemic affected different populations from a physical and psychological point of view. Psychological characteristics can have an impact on adjustment to illness conditions and increase the risk of persistence of physical symptoms and psychopathology.
Healthcare workers (HCWs) may have a higher risk of developing long COVID due to greater exposure to COVID-19, with symptoms extending beyond the acute phase impacting their daily living activities and job performance. To systematically map the existing literature on the impact of long COVID on HCWs' job performance, focusing on their time to return to work and work ability.
Long COVID is clinically heterogeneous, but longitudinal changes in documented chronic disease burden and transitions in multimorbidity phenotypes after infection are not well characterized in routine care. We considered 425,614 patients with clinician-coded long COVID (ICD-10-CM U09.9) and a definable COVID-19 index date between October 1, 2021 and September 16, 2024 using deidentified electronic health record data...
We evaluated the influence of single-nucleotide polymorphisms in cytokine, renin-angiotensin-aldosterone system, and uromodulin genes on COVID-19 severity and the persistence of symptoms in the post-COVID phase. Two cross-sectional cohort studies were conducted: a retrospective cohort (cohort 1) from early phase of the pandemic and a prospective cohort (cohort 2) including patients with symptoms in the post-COVID...
Cardiovascular complications associated with Post-COVID-19 Patients remain difficult to identify at early stages due to heterogeneous physiological manifestations and the limited integration of imaging and clinical indicators in conventional diagnostic frameworks. To address this challenge, this work proposes a multimodal deep learning framework for cardiovascular disease (CVD) risk prediction by integrating cardiac...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a common sequela following COVID-19. Although cognitive dysfunction is one of the most debilitating symptoms in ME/CFS, effective therapies are limited.
Cognitive impairment is common in long COVID and severely affects daily life, with no proven treatments to date. To evaluate the ability of cognitive rehabilitation (CR) to improve goal attainment, cognitive, and clinical outcomes in individuals with cognitive impairment as part of long COVID.
Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatocellular injury, inflammation, and progressive fibrosis, yet current non-invasive tests do not directly assess the cellular drivers of fibrogenesis. Platelet-derived growth factor receptor beta (PDGFRβ) is highly expressed on activated hepatic stellate cells (aHSC), a major effector cell population in MASH.
Seeing beyond the COVID-19 pandemic as an extraordinary spectacle situated in the past, we draw on qualitative research with young people to trace experiences of Long Covid as 'looping effects' of entangling physical and social impacts which intersect with, and extend, those of pandemic. Navigating the capacity to do ordinary things becomes highly contingent, and exhausting work, in the face of Long Covid.
Loneliness, distinct from social isolation, is a subjective sense of social disconnection exacerbating a public health crisis among older adults. Affecting ~33% of community-dwelling individuals aged 50-80 years post-COVID-19, it rivals smoking in mortality risk and drives cognitive, cardiovascular, and mental health declines.
Pancreatic cancer (PaC) remains one of the deadliest cancers, with 5-year survival rates of 13%. A major driver of its aggressiveness is the tumour microenvironment (TME), which fuels tumour growth, metastasis, and therapeutic resistance through dynamic, bi-directional communication between cancer cells, fibroblasts, and immune cells.
The objective of this research is to examine comorbidity status of hospitalized Covid-19 patients and its association with post-Covid-19 health complications. Data were collected from 1207 Covid-19 patients who were hospitalized at Dhaka Medical College Hospital (DMCH), Bangladesh from May 2020 to April 2021.
Long COVID syndrome has a multifactorial cause that is not fully understood and may be influenced by both external and intrinsic factors. In this context, a Genome-Wide Association Study (GWAS) was proposed to evaluate the association between Single Nucleotide Polymorphisms (SNPs) in TMPRSS2 (rs12329760 and rs2070788) and the occurrence of Long COVID in 363 Brazilian healthcare professionals, recruited using a...
The cofactors potentially affecting exercise performance after COVID-19 are still incompletely investigated. The contribution of several clinical and demographic variables to the exercise capacity measured with the 6-min walk test was assessed in multivariable analyses that used the absolute distance walked in 6 min (6MWD) and an impaired performance (6MWD < 60% of the predicted value) as study outcomes.
Lytic polysaccharide monooxygenases (LPMOs) are crucial for recalcitrant biomass degradation. We characterized CmLPMO10, an AA10 LPMO from Chitinibacter mangrovi FCG-7, and demonstrated its essential role in α-chitin utilization through transcriptomics and gene deletion.
The intracavitary cardiac metastasis from squamous cell carcinoma of the uterine cervix combined with pulmonary embolism is extremely rare, with mean survival less than six months. We report a case of a 52-year-old female with stage IVB cervical squamous cell carcinoma (SCC) and cardiac metastasis presented with exertional dyspnea and chest pain concerning pulmonary embolism (PE) post COVID-19 infection.
The 2025 clinical guideline for primary aldosteronism (PA) recommends a diagnostic and therapeutic pathway stratified by lateralization risk. The PA severity classification (PASC) integrates biochemical and clinical features and is intended to inform graded recommendations for adrenal venous sampling (AVS).
Cognitive impairment is frequent in post-COVID-19 syndrome (PCS). The understanding of the pathogenesis is still limited.
Temporal responses of serum iron and ferritin in COVID-19 infection and vaccination remain insufficiently characterized. This case report presents their timeline after SARS-CoV-2 and influenza vaccinations and may serve as a model for future studies.
Progressive supranuclear palsy (PSP) is a rare neurodegenerative tauopathy characterized by early postural instability, vertical supranuclear gaze palsy, axial rigidity, and poor response to levodopa therapy. Diagnosis remains challenging, particularly in the early stages, because of overlap with other Parkinsonian syndromes.
SARS-CoV-2 is frequently associated with cognitive impairment. When symptoms persist for more than four weeks after acute infection, a Long-COVID condition is diagnosed.
Local inhibition of the "patching" function of tumor-associated platelets against neutrophil infiltration-caused vascular breaches has been used as an "enhanced permeability and retention (EPR) amplification" strategy. Nevertheless, the vascular leakage-resulted elevation of interstitial fluid pressure (IFP) could impact tumoral perfusion and convection of nanodrugs.
COVID-19 and long COVID have had an impact worldwide on people's participation in occupations. Occupational therapists play a role in supporting individuals' recovery and participation in daily life.
The long-term clinical burden of Coronavirus disease (COVID-19) remains substantial, yet one-year cohort evidence linking blood-based biomarkers to persistent sequelae is limited. We conducted a longitudinal study in adults aged 18-80 years who were classified as moderate or severe COVID-19 or non-COVID-19 controls.
SARS-CoV-2 (COVID-19) infection increases thrombotic risk; however, its impact on microsurgical breast reconstruction outcomes remains unclear. This study examines postoperative complications in patients following abdominal-based microvascular breast reconstruction relative to (1) timing relative to the COVID-19 pandemic, (2) history of COVID-19 infection, and (3) time since COVID-19 vaccination/booster.
Idiopathic anaphylaxis (IA) is a diagnosis of exclusion, and the etiology remains elusive. Research on immunoglobulin E (IgE)-mediated anaphylaxis has identified histamine as the immune system mediator, but dietary histamine's potential role in IA is often overlooked.
Infection with SARS-CoV-2 may result in persistent functional impairment after the acute phase of the disease. Emerging evidence suggests that the presence and intensity of COVID-19-related symptoms may be associated with deficits in muscle strength and physical performance during the post-infection period.
The COVID-19 pandemic has imposed a substantial worldwide health burden; a fraction of people develops post-COVID syndrome, in which symptoms persist long after the initial phase of infection. Although these individuals may be more susceptible to developing thromboembolic events, the extent and significance of this link remain uncertain.
Long COVID is a chronic illness affecting multiple organ systems, which can be at odds with a highly specialized and siloed U.S. healthcare system. Patients frequently see multiple specialists for diverse symptoms, creating substantial coordination challenges.
Full feed: ME/CFS research tracker
Patients with Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) experience significant sensory problems that affect their personal, social and occupational life. However, there is no clear understanding of how the sensory problems manifest in ME/CFS.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood.
Full feed: Lyme / PTLDS research tracker
Acute Lyme disease is caused by a
Borreliosis, also known as Lyme disease, is a chronic, multi-organ illness that is very difficult to diagnose. It is caused by the spirochete Serum for the study was obtained from 99 randomly selected patients who reported for routine testing at the medical diagnostic laboratory in Krynica-Zdrój.
Full feed: POTS research tracker
There is a growing body of literature evaluating both postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndrome (EDS). We conducted a systematic review to evaluate what is currently known about the co-existence of both conditions.
Qualitative thematic analysis is widely used in health research to examine patient experiences and inform the refinement of digital health interventions, but it is time- and labor-intensive. Large language models (LLMs) may help accelerate this process, yet their performance may depend not only on the model itself but also on how the analytic workflow is structured.
Hypermobile Ehlers-Danlos syndrome (hEDS), frequently presents with pain and autonomic symptoms suggestive of small fiber neuropathy (SFN). However, systematic comparisons between hEDS and idiopathic SFN (iSFN) using combined clinical, functional, and morphological approaches are lacking.
Postural tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by orthostatic intolerance and frequently accompanied by a broad constellation of debilitating symptoms. Emerging evidence suggests that dysregulation within central-autonomic regulatory networks may contribute to symptom persistence.
Postural orthostatic tachycardia syndrome (POTS) is associated with autonomic dysregulation, but ambulatory markers that capture autonomic phenotype remain incompletely defined. To compare Holter-derived heart rate variability (HRV) metrics between adolescents with POTS and healthy controls and to derive candidate discriminatory thresholds.
Autonomic dysfunction, or dysautonomia, is increasingly being recognized as a complication of concussion. While the symptoms can overlap with other postconcussion sequelae, it is important to distinguish the patient suffering from postconcussion dysautonomia in order to provide proper symptomatic management and aid in recovery.
Postural tachycardia syndrome (POTS) is a common, often disabling disorder of autonomic nervous system regulation without a unifying etiological account. Converging evidence suggests infectious, physical, and emotional threats frequently precede onset.
Pelvic venous disorders (PeVD) are recognised causes of chronic pelvic pain; emerging evidence suggests that venous outflow obstruction or reflux can also provoke orthostatic intolerance (OI) by infra-diaphragmatic pooling and reduced preload. Diagnostic and therapeutic frameworks for this overlap remain poorly defined.
Full feed: MCAS research tracker
Gut dysbiosis is increasingly recognized as a key contributor to food allergy, yet probiotic strains capable of restoring allergic microbiota and rebalancing host immunity remain limited. Here, we identified Lactiplantibacillus plantarum SLpl116 through a multi-criteria screening pipeline integrating anti-allergic activity, safety, and processing stability, and evaluated its efficacy in a prophylactic ovalbumin...
Type 2 diabetes mellitus (T2DM) complicated by muscle atrophy (diabetic sarcopenia) significantly increases mortality risk, with immunometabolic imbalance-driven disruption of the skeletal muscle microenvironment as a core mechanism. This review focuses on the immune cell-myocyte crosstalk network to elucidate the pathological mechanisms of T2DM-induced muscle atrophy, the local remodeling effects of exercise, and...
Cholangiocarcinoma (CCA) is a common and highly refractory malignancy; however, biomarkers and therapeutic targets associated with its progression remain incompletely understood. Crotonylation is an emerging lysine acylation modification that has been implicated in multiple diseases.
Atopic dermatitis (AD) is a complex inflammatory skin disorder. Rhodiola crenulata extract (RC) contains bioactive compounds with potential benefits for AD, but its mechanisms are not fully elucidated.
A variety of clinical signs and symptoms have been described in patients suspected of having mast cell activation syndrome (MCAS), however, symptom patterns and linked organ systems were not yet described. This cross-sectional online survey included adults with physician-diagnosed self-assessed or suspected MCAS between June and September 2021.
Bradykinin is a nonapeptide of the kinin family with vasoactive and proinflammatory activities. While generation of kinins is mainly driven by activation of the contact system and plasma or tissue kallikreins, additional independent cascades contribute to their formation.
Chronic spontaneous urticaria (CSU) presents recurrent wheals and/or angioedema for more than six weeks without an identifiable trigger. Although mast cell activation and histamine release are well-established effector mechanisms, this model does not explain disease persistence, immune dysregulation, or treatment refractoriness.
Frequent and excessive skin exposure to ultraviolet radiation induces oxidative stress and inflammation, raising skin diseases. Therapeutic strategies targeting both oxidative stress and inflammation may reduce skin disorders.
No abstract available.
This study investigated the clinical significance of miR-431-5p in childhood asthma and its cell function in house dust mite (HDM)-induced cell models. Differential miRNA expression was analyzed in the GSE263408 dataset using bioinformatics tools (Limma package).
Acupuncture and moxibustion are evidence - based modalities derived from traditional Chinese medicine. They employ strategic needle insertion or moxa - derived thermal stimulation at specific acupoints to ameliorate pathological conditions.
Middle cerebral artery stenosis (MCA-S) impairs cerebral perfusion and vascular pulsatility, potentially disrupting cerebrospinal fluid dynamics. We evaluated perivascular diffusivity in MCA-S using diffusion tensor image analysis along the perivascular space (DTI-ALPS) index and the redirected ALPS (ro-ALPS) index, and assessed their clinical correlations.
Zinc oxide nanoparticles (ZnONPs) are widely used in sunscreens and cosmetics; however, increasing evidence suggests their potential to induce skin toxicity, particularly under conditions of skin function disruption. Here, we investigated the mechanisms underlying allergic skin inflammation triggered by repeated ZnONPs exposure following UVR damage using an in vivo hairless mouse model and in vitro Adverse Outcome...
Eosinophils amplify type-2 (Th2) inflammation and tissue injury in allergic rhinitis (AR), and eosinophilic burden correlates with disease severity and future asthma risk. Current AR therapies have limitations, motivating interest in non-pharmacologic neuromodulatory approaches.
Mast cell elimination through Siglec-6 is a minimally explored strategy for diseases characterized by mast cell overactivity or overproduction. Here, we combine nanotechnology with cell-free protein synthesis to develop a therapeutic strategy (anti-Sig6-NPmidoFab) for selectively eliminating mast cells.
This study investigated the potential protective role of rosmarinic acid (RA) against oxidative stress, inflammation, and fibrosis induced by ionizing radiation in an experimental rat model. A total of 42 male Sprague-Dawley rats were randomly divided into seven groups (n = 6): G0, G1(14), G1(28), G2(14), G2(28), G3(14), and G3(28).
Systemic mastocytosis (SM) is a clonal disorder characterized by abnormal accumulation of mast cells in various tissues and is categorized into distinct subtypes per the World Health Organization (WHO) 2022 classification. When SM is associated with another hematologic neoplasm, typically of myeloid lineage, it is classified as systemic mastocytosis with an associated hematologic neoplasm (SM-AHN).
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is considered the only curative option for certain malignant hematopoietic disorders, yet its benefits are limited by the development of graft-versus-host disease (GVHD). Chronic GVHD (cGVHD) is often characterized by chronic inflammation and fibrosis, propagated by alloreactive donor B- and T-cell involvement.
No abstract available.
No abstract available.
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