Research Tracker›Biomarker Atlas›ME/CFS›Urinary metabolite panel

Urinary metabolite panel in ME/CFS

Urinary metabolite panel, also described as Metabolomic signature, belongs to the urinary group of ME/CFS (ME/CFS, CFS) markers, but reports against healthy controls point in different directions. Symptom domains tied to this marker in the source include non-invasive disease signature. This entry summarises Taccori et al. 2023. Group-level associations like this do not translate into an individual diagnostic cut-off.

↕ InconsistentUrinary

Summary

Direction in ME/CFS↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction
CategoryUrinary
Also described asMetabolomic signature
Compared againstHC (healthy controls)
Associated symptomsNon-invasive disease signature
Test typeTissue / pathology test
SourceTaccori et al. 2023 — doi:10.1186/s12967-023-04398-7
Condition atlasME/CFS Biomarker Atlas

Related Urinary markers in ME/CFS

Full list: ME/CFS Biomarker Atlas.

Frequently asked questions

Is Urinary metabolite panel high or low in ME/CFS?

Mixed. Some studies report higher and others lower Urinary metabolite panel in ME/CFS compared with healthy controls, so no single direction is established. Source: Taccori et al. 2023.

What symptoms is Urinary metabolite panel associated with in ME/CFS?

The cited literature associates this marker with Non-invasive disease signature. These are population-level associations and do not mean the marker causes the symptoms.

Which test measures Urinary metabolite panel?

It is measured as a tissue / pathology test. Many of the cited studies used research-grade assays, so clinical availability may vary.

Is one abnormal Urinary metabolite panel result diagnostic of ME/CFS?

No. No single biomarker is diagnostic of ME/CFS. Urinary metabolite panel findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Urinary metabolite panel in ME/CFS: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/me-cfs/urinary-metabolite-panel.html
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Last reviewed: 2026-06-29 · Page generated from me-cfs.json · Browse: ME/CFS atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.