Research Tracker›Biomarker Atlas›ME/CFS›Urinary creatinine-normalized metabolites

Urinary creatinine-normalized metabolites in ME/CFS

In ME/CFS (ME/CFS, CFS), the direction of change for Urinary creatinine-normalized metabolites, also described as Metabolomic ratios, is inconsistent across studies that used healthy controls as the reference group. Symptom domains tied to this marker in the source include metabolic pathway alterations. The finding is drawn from Taccori et al. 2023; it describes group-level differences, not a threshold that classifies an individual.

↕ InconsistentUrinary

Summary

Direction in ME/CFS↕ Inconsistent — reported as both higher and lower across studies, with no consistent direction
CategoryUrinary
Also described asMetabolomic ratios
Compared againstHC (healthy controls)
Associated symptomsMetabolic pathway alterations
Test typeTissue / pathology test
SourceTaccori et al. 2023 — doi:10.1186/s12967-023-04398-7
Condition atlasME/CFS Biomarker Atlas

Related Urinary markers in ME/CFS

Full list: ME/CFS Biomarker Atlas.

Frequently asked questions

Is Urinary creatinine-normalized metabolites high or low in ME/CFS?

Mixed. Some studies report higher and others lower Urinary creatinine-normalized metabolites in ME/CFS compared with healthy controls, so no single direction is established. Source: Taccori et al. 2023.

What symptoms is Urinary creatinine-normalized metabolites associated with in ME/CFS?

The cited literature associates this marker with Metabolic pathway alterations. These are population-level associations and do not mean the marker causes the symptoms.

Which test measures Urinary creatinine-normalized metabolites?

It is measured as a tissue / pathology test. Many of the cited studies used research-grade assays, so clinical availability may vary.

Is one abnormal Urinary creatinine-normalized metabolites result diagnostic of ME/CFS?

No. No single biomarker is diagnostic of ME/CFS. Urinary creatinine-normalized metabolites findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Urinary creatinine-normalized metabolites in ME/CFS: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/me-cfs/urinary-creatinine-normalized-metabolites.html
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Last reviewed: 2026-06-29 · Page generated from me-cfs.json · Browse: ME/CFS atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.