Summary
| Direction in ME/CFS | ↓ Reduced — lower than in the comparison group |
|---|---|
| Category | Metabolic |
| Also described as | Amino acid |
| Compared against | HC — LC overlap (healthy controls; long COVID overlap) |
| Associated symptoms | Cognitive dysfunction, fatigue |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Saito et al. 2024 — doi:10.3389/fimmu.2024.1341843 |
| Condition atlas | ME/CFS Biomarker Atlas |
Other conditions where Serine is reported
- Serine in Long COVID — ↓ reduced vs HC, R
See the cross-condition hub: Serine across conditions.
Trials, interventions and tests
In clinical-trial registrations this marker maps to the outcome term Neuropeptide Y (1 registered trials use a matching outcome measure).
Clinical trials using Serine as an outcome
- NCT03496961: Yan Nian Jiu Zhuan Fa Improve Chronic Fatigue Syndromes (Unknown)
Outcome measure: Neuropeptide Y
Also sold as a nutrient or supplement
Serine (amino acid). Amino acid supplement (powder or capsule). This tag means the analyte is also available orally; it is not a product endorsement and a low or high level does not by itself justify supplementation.
Related Metabolic markers in ME/CFS
- Sarcosine ↓
- Kynurenine ↑
- Lactate (blood) ↑
- Free carnitine ↕
- C18 Acylcarnitine (stearoylcarnitine) ↑
- C16 Acylcarnitine (palmitoylcarnitine) ↑
- Acylcarnitines (composite) ↑
- Ceramides (plasma) ↓
Full list: ME/CFS Biomarker Atlas.
Frequently asked questions
Is Serine high or low in ME/CFS?
Reduced. Studies summarised in the OSMF atlas report lower Serine in ME/CFS than in healthy controls; long COVID overlap. Source: Saito et al. 2024.
What symptoms is Serine associated with in ME/CFS?
The cited literature associates this marker with Cognitive dysfunction, fatigue. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Serine?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Serine result diagnostic of ME/CFS?
No. No single biomarker is diagnostic of ME/CFS. Serine findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is Serine specific to ME/CFS?
No. The same marker is also reported in Long COVID in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
Cite this page
Subscribe on Substack
Last reviewed: 2026-06-29 · Page generated from me-cfs.json · Browse: ME/CFS atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.