Serine across conditions

Serine appears in 2 entries of the OSMF biomarker atlas, covering Long COVID, ME/CFS. Across those entries it is reduced in 2. Because the same marker shifts in several unrelated conditions, it is best understood as a signal of shared biology such as inflammation, vascular or metabolic stress rather than as a condition-specific test. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Long COVIDME/CFS

Where Serine is reported

Also listed as: Amino acid

ConditionDirectionCompared againstAssociated symptomsSource
Long COVID↓ reducedhealthy controls, recovered individuals without persistent symptomsFatigue, depression, cognitive dysfunctionSaito et al. 2024
ME/CFS↓ reducedhealthy controls; long COVID overlapCognitive dysfunction, fatigueSaito et al. 2024

Frequently asked questions

In which conditions is Serine altered?

In the OSMF atlas Serine is reported in Long COVID, ME/CFS. It is reduced in 2 across 2 entries.

Does Serine point to one specific diagnosis?

No. Because Serine changes in several conditions (Long COVID, ME/CFS), an abnormal result cannot identify which condition, if any, is present. It must be interpreted with symptoms, history and other tests.

Is there a standard clinical test for Serine?

The atlas entries for Serine do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal Serine result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). Serine across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/serine.html
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Last reviewed: 2026-06-29 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.