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FIB-4 Index: biomarker evidence

FIB-4 Index appears in 1 entry of the OSMF biomarker atlas, covering Hepatitis C. Across those entries it is elevated in 1. It is currently reported in a single condition in this atlas; cross-condition comparison will be added as the dataset grows. Each row below links to a page with the comparison group, associated symptoms, test details and primary citation.

Hepatitis C

Where FIB-4 Index is reported

Also listed as: FIB-4

ConditionDirectionCompared againstAssociated symptomsSource
Hepatitis C↑ elevatedchronic HCV patients with advanced liver fibrosis vs early-stage disease (FIB-4 <1.45)—Krassenburg et al. 2023

Frequently asked questions

In which conditions is FIB-4 Index altered?

In the OSMF atlas FIB-4 Index is reported in Hepatitis C. It is elevated in 1 across 1 entries.

Is there a standard clinical test for FIB-4 Index?

The atlas entries for FIB-4 Index do not carry a LOINC code, which usually means the marker was measured with research assays or study-specific methods rather than a routine clinical panel.

Is one abnormal FIB-4 Index result diagnostic?

No single biomarker result is diagnostic of any of these conditions. Findings reflect group averages from published cohorts with substantial overlap between patients and controls.

Cite this page

Open Source Medicine Foundation. (2026). FIB-4 Index across conditions: biomarker evidence. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/markers/fib-4-index.html
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Last reviewed: 2026-07-03 · Browse: Biomarker Index · All marker pages · Biomarker Atlas

Disclaimer: Educational synthesis of peer-reviewed research; not medical advice. Findings are group-level and vary with study design. Discuss any result with a qualified clinician.