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Lyme arthritis RF/anti-CCP in Lyme Disease

In Lyme Disease (Lyme borreliosis, Borrelia burgdorferi infection), published studies report lower levels of Lyme arthritis RF/anti-CCP, also described as Rheumatoid panel, than in RA patients. Clinically, it has been associated with negative — helps distinguish RA. The finding is drawn from Lantos et al. 2021; it describes group-level differences, not a threshold that classifies an individual.

↓ ReducedFunctional

Summary

Direction in Lyme Disease↓ Reduced — lower than in the comparison group
CategoryFunctional
Also described asRheumatoid panel
Compared againstRA patients
Associated symptomsNegative — helps distinguish RA
Test typeClinical or physiological test
SourceLantos et al. 2021 — doi:10.1016/j.idc.2021.05.001
Condition atlasLyme Disease Biomarker Atlas

Related Functional markers in Lyme Disease

Full list: Lyme Disease Biomarker Atlas.

Frequently asked questions

Is Lyme arthritis RF/anti-CCP high or low in Lyme Disease?

Reduced. Studies summarised in the OSMF atlas report lower Lyme arthritis RF/anti-CCP in Lyme Disease than in RA patients. Source: Lantos et al. 2021.

What symptoms is Lyme arthritis RF/anti-CCP associated with in Lyme Disease?

The cited literature associates this marker with Negative — helps distinguish RA. These are population-level associations and do not mean the marker causes the symptoms.

Which test measures Lyme arthritis RF/anti-CCP?

It is measured as a clinical or physiological test. Many of the cited studies used research-grade assays, so clinical availability may vary.

Is one abnormal Lyme arthritis RF/anti-CCP result diagnostic of Lyme Disease?

No. No single biomarker is diagnostic of Lyme Disease. Lyme arthritis RF/anti-CCP findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Lyme arthritis RF/anti-CCP in Lyme Disease: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/lyme/lyme-arthritis-rf-anti-ccp.html
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Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.