Research Tracker›Biomarker Atlas›Lyme Disease›Facial palsy + CSF pleocytosis

Facial palsy + CSF pleocytosis in Lyme Disease

Facial palsy + CSF pleocytosis, also described as Clinical-laboratory composite, is a functional marker reported as elevated in Lyme Disease (Lyme borreliosis, Borrelia burgdorferi infection) when patients are compared with Bell's palsy non-Lyme. The cited literature links this alteration to lyme neuroborreliosis. This entry summarises Lantos et al. 2021. Group-level associations like this do not translate into an individual diagnostic cut-off.

↑ ElevatedFunctional

Summary

Direction in Lyme Disease↑ Elevated — higher than in the comparison group
CategoryFunctional
Also described asClinical-laboratory composite
Compared againstBell's palsy non-Lyme
Associated symptomsLyme neuroborreliosis
Test typeClinical or physiological test
SourceLantos et al. 2021 — doi:10.1016/j.idc.2021.05.001
Condition atlasLyme Disease Biomarker Atlas

Related Functional markers in Lyme Disease

Full list: Lyme Disease Biomarker Atlas.

Frequently asked questions

Is Facial palsy + CSF pleocytosis high or low in Lyme Disease?

Elevated. Studies summarised in the OSMF atlas report higher Facial palsy + CSF pleocytosis in Lyme Disease than in Bell's palsy non-Lyme. Source: Lantos et al. 2021.

What symptoms is Facial palsy + CSF pleocytosis associated with in Lyme Disease?

The cited literature associates this marker with Lyme neuroborreliosis. These are population-level associations and do not mean the marker causes the symptoms.

Which test measures Facial palsy + CSF pleocytosis?

It is measured as a clinical or physiological test. Many of the cited studies used research-grade assays, so clinical availability may vary.

Is one abnormal Facial palsy + CSF pleocytosis result diagnostic of Lyme Disease?

No. No single biomarker is diagnostic of Lyme Disease. Facial palsy + CSF pleocytosis findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.

Cite this page

Open Source Medicine Foundation. (2026). Facial palsy + CSF pleocytosis in Lyme Disease: direction, evidence and what it means. OSMF Research Tracker. Retrieved October 7, 2026, from https://research.opensourcemed.info/biomarkers/lyme/facial-palsy-csf-pleocytosis.html
Get OSMF research updates. New biomarker, trial and treatment evidence summaries by email.
Subscribe on Substack

Last reviewed: 2026-06-29 · Page generated from lyme.json · Browse: Lyme Disease atlas · Biomarker Index · All marker pages

Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.