Summary
| Direction in Long COVID | ↑ Elevated — higher than in the comparison group |
|---|---|
| Category | Immune |
| Also described as | G-protein coupled receptor Abs |
| Compared against | HC (healthy controls) |
| Associated symptoms | Dysautonomia, POTS |
| Test type | Blood test (serum / plasma / whole blood) |
| Source | Wilhelm et al. 2026 — doi:10.1016/S1473-3099(25)00411-6 |
| Condition atlas | Long COVID Biomarker Atlas |
Other conditions where Anti-GPCR autoantibodies (panel) is reported
- Anti-GPCR autoantibodies (panel) in ME/CFS — ↑ elevated vs HC — LC/PACVS overlap
- Anti-GPCR autoantibodies (panel) in PACVS — ↑ elevated vs HC
See the cross-condition hub: Anti-GPCR autoantibodies (panel) across conditions.
Related Immune markers in Long COVID
- Anti-IFN-ω autoantibodies ↑
- β2-microglobulin ↑
- Anti-IFN-α autoantibodies ↑
- Complement C3a / C5a ↑
- T cell exhaustion markers ↑
- Low naive T cells / High effector memory ↕
Full list: Long COVID Biomarker Atlas.
Frequently asked questions
Is Anti-GPCR autoantibodies high or low in Long COVID?
Elevated. Studies summarised in the OSMF atlas report higher Anti-GPCR autoantibodies in Long COVID than in healthy controls. Source: Wilhelm et al. 2026.
What symptoms is Anti-GPCR autoantibodies associated with in Long COVID?
The cited literature associates this marker with Dysautonomia, POTS. These are population-level associations and do not mean the marker causes the symptoms.
Which test measures Anti-GPCR autoantibodies?
It is measured as a blood test (serum / plasma / whole blood). Many of the cited studies used research-grade assays, so clinical availability may vary.
Is one abnormal Anti-GPCR autoantibodies result diagnostic of Long COVID?
No. No single biomarker is diagnostic of Long COVID. Anti-GPCR autoantibodies findings come from group comparisons, overlap considerably between patients and controls, and vary with study design, timing and comparison group. A result should be interpreted by a clinician alongside symptoms, history and other tests.
Is Anti-GPCR autoantibodies specific to Long COVID?
No. The same marker is also reported in ME/CFS, PACVS in this atlas, so it reflects shared biology (for example inflammation or vascular stress) rather than a condition-specific signature.
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Last reviewed: 2026-06-29 · Page generated from long-covid.json · Browse: Long COVID atlas · Biomarker Index · All marker pages
Disclaimer: This page is an educational synthesis of published, peer-reviewed research and is not medical advice. Biomarker findings vary across studies with case definitions, comparison groups, timing and assay methods. Direction of change reflects the predominant finding in the cited source and does not establish a diagnostic threshold. Discuss any test result with a qualified clinician.