Evidence Summary
Evidence Level: Anecdotal
Mechanism: Not specified
Safety: Limited specific safety data in these populations. Review full prescribing information and consult specialist. Many agents used off-label or investigational.
Dosing: See linked studies/trials for reported doses and durations; typical protocols vary widely.
Single-blind RCT n=56 showed large fatigue reduction (8.7% vs 80.1% placebo) and 6MWT gains; targets documented arginine depletion. Doses studied ~1-2g L-arginine + vit C. Promising for fatigue; OTC, low cost. Replication warranted.