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Cohorts by trigger

Pandemrix (AS03-adjuvanted H1N1 influenza vaccine)

Vaccine · intramuscular injection · 1 cohort · 1 observations · CC BY 4.0

All PAIS cohorts in this database triggered by Pandemrix (AS03-adjuvanted H1N1 influenza vaccine). Flags mark evidentiary caveats (preprint, grey literature, patient-reported, uncontrolled, etc.).

Finland Pandemrix childhood narcolepsy cohort (Nohynek)

Registry linkage · N=67 · control Unexposed (unmatched) · 1 obs · max follow-up n/r mo

Measures: Narcolepsy (incident)

Population registry-linkage cohort covering all Finnish children in the birth range, comparing narcolepsy incidence between Pandemrix-vaccinated and unvaccinated children (vaccine coverage 75%). Included to span the vaccine trigger class: the strongest example of an immune-mediated (autoimmune) post-exposure sequela with a defined denominator and an unvaccinated comparator. Of 67 confirmed cases, 46 vaccinated and 7 unvaccinated entered the primary analysis.

Susceptibility & conversion predictors

FactorContrastWindowOutcomeDirectionQuestionTemporalityCohort
HLA-DQB1*06:02 carriageHLA-DQB1*06:02 positive vs negativeGenetic / fixedNarcolepsy (incident)↑ increases riskConversion (given infection → syndrome)validFinland Pandemrix childhood narcolepsy cohort

PAIS Cohort Database v2 · back to table