Johns Hopkins SLICE early-Lyme cohort (Aucott/Rebman)
Prospective (inception) · N=234 · control Healthy convenience · 1 obs · max follow-up 12 mo
Measures: Impaired quality of life
Prospective inception cohort of ideally-treated early Lyme disease with a non-Lyme comparison group and a bio-repository, designed specifically to estimate the incidence of post-treatment Lyme disease. Functionally-impairing persistent symptoms occurred in 14% of treated patients vs 4% of controls, giving a rigorous denominator for PTLD that most Lyme literature lacks.