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Colombo Dengue Study (CDS)
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Design notes & limitations. Prospective cohort with a same-setting non-dengue febrile comparator, enabling a relative-risk estimate for post-infection fatigue. Short (2-month) follow-up captures early convalescence only.
Identity & trigger
- Cohort id
colombo-dengue- Aliases
- CDS
- Outbreak / event
- n/r
- Pathogen
- Dengue virus (Virus)
- Exposure ascertainment
- Mixed
Design
- Design
- Prospective (non-inception)
- Denominator defined
- Yes
- Denominator method
- Adults presenting with acute febrile illness (<3 days) clinically suspected as dengue; dengue confirmed vs non-dengue by laboratory testing.
- Recruitment
- hospital
- Time zero
- Onset of acute febrile illness (week)
- Control group
- Other-disease
Size & attrition
- Enrolled
- 260
- Analysed / enrolled
- 260/260 (100%)
- Max follow-up (months)
- 2
Biospecimens
- Specimens
- Yes
- Types
- serum, plasma
- Acute-phase specimens
- Yes
- Biobank
- Unknown
- External access
- Unknown
Observations (1)
Symptoms
32% Proportion
- Measure
- Fatigue sym:fatigue
- As worded
- “fatigue at 2 months post-infection”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=158
- Timing
- 2 mo (0-3 mo) · ref Not reported
- Method
- Unclear · Chalder Fatigue Scale
- Comparator
- no comparator
- Comparability signature
- 6c7f18611e — measure sym:fatigue · Unclear · ref Not reported · denom Assessed at timepoint · 0-3 mo · Proportion
- Provenance
- Results/Abstract (51/158 dengue patients; RR 4.93, 95% CI 2.3–10.4 vs non-dengue) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Sigera PC, Rajapakse S, Weeratunga P, et al. (2021). Dengue and post-infection fatigue: findings from a prospective cohort—the Colombo Dengue Study. Transactions of the Royal Society of Tropical Medicine and Hygiene. PMID 33099653 · DOI 10.1093/trstmh/traa110 primary
Provenance & verification
- Registration
- n/r
- Funders
- n/r
- Related cohorts
- none
- Symptom-inventory scope
- Single domain
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)