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French Polynesia Zika–Guillain-Barré case-control study
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Design notes & limitations. Case-control design (42 GBS cases; two control groups of 98 age/sex/island-matched patients and 70 Zika-positive patients without neurological signs). Establishes the causal link between Zika infection and an acute post-infectious immune sequela (GBS) rather than a chronic fatigue/pain syndrome; included to span the immune-neurological end of the PAIS spectrum. No longitudinal follow-up of chronic outcomes in this report.
Identity & trigger
- Cohort id
cao-lormeau-zika-gbs- Aliases
- Cao-Lormeau Zika GBS study
- Outbreak / event
- French Polynesia Zika outbreak 2013-14
- Pathogen
- Zika virus (Virus)
- Exposure ascertainment
- Mixed
Design
- Design
- Case-control
- Denominator defined
- No
- Denominator method
- n/r
- Recruitment
- hospital
- Time zero
- Onset of Guillain-Barré syndrome (cases); preceding transient illness compatible with Zika ~6 days earlier (week)
- Control group
- Other-disease
Size & attrition
- Enrolled
- 42
- Analysed / enrolled
- 42/42 (100%)
- Max follow-up (months)
- n/r
Biospecimens
- Specimens
- Yes
- Types
- serum
- Acute-phase specimens
- Yes
- Biobank
- Unknown
- External access
- Unknown
Observations (1)
Events
98% Proportion
- Measure
- Guillain-Barré syndrome event:guillain-barre-syndrome
- As worded
- “Guillain-Barré syndrome patients with serological evidence of recent Zika virus infection (anti-ZIKV IgM or IgG)”
- Population
- whole cohort · denominator Assessed at timepoint · N=n=42
- Timing
- 0 mo (Acute) · ref Not reported
- Method
- Unclear · Brighton Collaboration criteria for Guillain-Barré syndrome
- Comparator
- no comparator
- Comparability signature
- 09e1ed521f — measure event:guillain-barre-syndrome · Unclear · ref Not reported · denom Assessed at timepoint · Acute · Proportion
- Provenance
- Results (41/42 GBS cases had anti-ZIKV IgM or IgG) · Manual · verified OSMF research-tracker (web-verified against source) on 2026-07-20
Publications
- Cao-Lormeau VM, Blake A, Mons S, et al. (2016). Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. The Lancet. PMID 26948433 · DOI 10.1016/S0140-6736(16)00562-6 primary
Provenance & verification
- Registration
- n/r
- Funders
- Labex IBEID, European Union
- Related cohorts
- none
- Symptom-inventory scope
- Single domain
- Last verified
- 2026-07-20 — OSMF research-tracker (web-verified against source)