Deaths / year
0
GBD (indicative unless refreshed)
DALYs / year
50
GBD
Pathogen
Helminth
Post-infectious
No post-acute phase
Persistent symptoms
—
Post-infectious syndrome & persistent symptoms
Whether a post-acute infection syndrome is documented and the literature proportion with persistent symptoms.
Post-acute status
Transient joint involvement; no defined post-acute syndrome (near eradication)
Classification
No post-acute phase
Onset
-
Persistent-symptom %
not quantified as a single figure (see notes)
Source: WHO GWEP
Therapeutic agents by stage
Vector control, prevention, acute treatment, and post-infectious care. Only agents with published evidence are shown by default.
Vector & transmission control
| Agent | Type | Status | Mechanism / role | Source |
|---|---|---|---|---|
| Guinea worm case containment & water filtration | Vector control | Approved | Prevent Cyclops ingestion; pipe filters | WHO GWEP |
Prevention
| Agent | Type | Status | Mechanism / role | Source |
|---|---|---|---|---|
| Safe water supply education | Prevention | Approved | Near-eradication via behavioral prevention | WHO EML / standard of care |
Acute phase
| Agent | Type | Status | Mechanism / role | Source |
|---|---|---|---|---|
| Manual worm extraction & wound carePreliminary | Supportive | Standard of care | No chemotherapeutic agent; gradual removal | WHO GWEP |
Associated drug targets (Open Targets): ITGB2, CARD14, IL1RN, CTSL, CTSV, TRPV3
Burden: IHME GBD (indicative seed unless refreshed) · Therapeutics: curated WHO EML / SOC + Open Targets pipeline · Post-infectious data: curated peer-reviewed literature · Ontology: MONDO_0016472 · Updated 2026-07-10. Associations, not a diagnostic test.